Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = O-demethylation rabeprazole sulfide

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
12 pages, 1952 KiB  
Article
An O-Demethylation Metabolite of Rabeprazole Sulfide by Cunninghamella blakesleeana 3.970 Biotransformation
by Ming Song, Hongxiang Zhu, Jian Wang, Weizhuo Xu and Wei Xu
Catalysts 2023, 13(1), 15; https://doi.org/10.3390/catal13010015 - 22 Dec 2022
Cited by 5 | Viewed by 2778
Abstract
To explore the potential metabolites from rabeprazole sulfide, seven strains of filamentous fungi were screened for their biotransformation abilities. Among these strains, Cunninghamella blakesleeana 3.970 exhibited the best result. Four different culture media were screened in order to identify the most optimal for [...] Read more.
To explore the potential metabolites from rabeprazole sulfide, seven strains of filamentous fungi were screened for their biotransformation abilities. Among these strains, Cunninghamella blakesleeana 3.970 exhibited the best result. Four different culture media were screened in order to identify the most optimal for subsequent research. Single factors such as the initial pH of culture media, culture time, inoculation volume, and media volume were individually investigated to provide the optimum biotransformation conditions. Then, an orthogonal optimization process using a five-factor, four-level L16(45) experiment was designed and performed. Finally, when the substrate concentration is 3 g/L, one major metabolite was detected with a transformation rate of 72.4%. Isolated by semipreparative HPLC, this metabolite was further detected by ESI-MS and NMR. The final data analysis indicated that the metabolite is O-demethylation rabeprazole sulfide. Full article
(This article belongs to the Special Issue Microbial Biocatalysis)
Show Figures

Figure 1

Back to TopTop