Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = O,N-(2-sulfoethyl)chitosan

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
28 pages, 4855 KiB  
Article
Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated Chitosan
by I. N. Bolshakov, L. M. Gornostaev, O. I. Fominykh and A. V. Svetlakov
Polymers 2022, 14(16), 3431; https://doi.org/10.3390/polym14163431 - 22 Aug 2022
Cited by 14 | Viewed by 2421
Abstract
This work is devoted to the chemical synthesis of sulfated chitosan and its experimental verification in an animal model of early atherosclerosis. The method of chitosan quaternization with sulfate-containing ingredients resulted in a product with a high content of sulfate groups. Implantation of [...] Read more.
This work is devoted to the chemical synthesis of sulfated chitosan and its experimental verification in an animal model of early atherosclerosis. The method of chitosan quaternization with sulfate-containing ingredients resulted in a product with a high content of sulfate groups. Implantation of this product into the fascial-muscular sheath of the main limb artery along the leg and thigh in rabbits led to the extraction of cholesterol from the subintimal region. Simplified methods for the chemical synthesis of quaternized sulfated chitosan and the use of these products in a model of experimental atherosclerosis made it possible to perform a comparative morphological analysis of the vascular walls of the experimental and control limbs under conditions of a long-term high-cholesterol diet. The sulfated chitosan samples after implantation were shown to change the morphological pattern of the intimal and middle membranes of the experimental limb artery. The implantation led to the degradation of soft plaques within 30 days after surgical intervention, which significantly increased collateral blood flow. The implantation of sulfated chitosan into the local area of the atherosclerotic lesions in the artery can regulate the cholesterol content in the vascular wall and destroy soft plaques in the subintimal region. Full article
(This article belongs to the Special Issue Biobased Materials for Emerging Applications)
Show Figures

Figure 1

Back to TopTop