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Keywords = Mitrephora vulpina

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2 pages, 191 KiB  
Correction
Correction: Moharam et al., Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation. Molecules 2010, 15, 7840-7848
by Bushra Abdulkarim Moharam, Ibrahim Jantan, Juriyati Jalil and Khozirah Shaari
Molecules 2014, 19(3), 3848-3849; https://doi.org/10.3390/molecules19033848 - 24 Mar 2014
Cited by 2 | Viewed by 5479
Abstract
The authors wish to inform readers that there are several minor errors and omissions in the chemical structures shown in Figure 1 of this paper [1]. [...] Full article
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9 pages, 173 KiB  
Article
Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation
by Bushra Abdulkarim Moharam, Ibrahim Jantan, Juriyati Jalil and Khozirah Shaari
Molecules 2010, 15(11), 7840-7848; https://doi.org/10.3390/molecules15117840 - 3 Nov 2010
Cited by 34 | Viewed by 9019 | Correction
Abstract
Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch. They were evaluated for their ability to inhibit platelet activating factor (PAF) receptor binding to rabbit platelets using 3H-PAF as a ligand [...] Read more.
Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch. They were evaluated for their ability to inhibit platelet activating factor (PAF) receptor binding to rabbit platelets using 3H-PAF as a ligand and their antiplatelet aggregation effect in human whole blood induced by arachidonic acid (AA), collagen and adenosine diphosphate (ADP). Of all the compounds tested, phylligenin and quebrachitol exhibited potent and concentration-dependent inhibitory effects on PAF receptor binding, with IC50 values of 13.1 and 42.2 µM, respectively. The IC50 value of phylligenin was comparable to that of cedrol (10.2 µM), a potent PAF antagonist. Phylligenin also showed strong dose-dependent inhibitory activity on platelet aggregation induced by AA and ADP. Full article
(This article belongs to the Section Natural Products Chemistry)
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