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Keywords = Holstein-Fröhlich model

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16 pages, 2413 KiB  
Article
Transition between Random and Periodic Electron Currents on a DNA Chain
by Elham Faraji, Roberto Franzosi, Stefano Mancini and Marco Pettini
Int. J. Mol. Sci. 2021, 22(14), 7361; https://doi.org/10.3390/ijms22147361 - 8 Jul 2021
Cited by 2 | Viewed by 2329
Abstract
By resorting to a model inspired to the standard Davydov and Holstein-Fröhlich models, in the present paper we study the motion of an electron along a chain of heavy particles modeling a sequence of nucleotides proper to a DNA fragment. Starting with a [...] Read more.
By resorting to a model inspired to the standard Davydov and Holstein-Fröhlich models, in the present paper we study the motion of an electron along a chain of heavy particles modeling a sequence of nucleotides proper to a DNA fragment. Starting with a model Hamiltonian written in second quantization, we use the Time Dependent Variational Principle to work out the dynamical equations of the system. It can be found that, under the action of an external source of energy transferred to the electron, and according to the excitation site, the electron current can display either a broad frequency spectrum or a sharply peaked frequency spectrum. This sequence-dependent charge transfer phenomenology is suggestive of a potentially rich variety of electrodynamic interactions of DNA molecules under the action of electron excitation. This could imply the activation of interactions between DNA and transcription factors, or between DNA and external electromagnetic fields. Full article
(This article belongs to the Special Issue Brain/Mind Activity and Molecular Dynamics in Biological Systems)
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