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Keywords = Hansfordia sinuosae

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13 pages, 570 KiB  
Article
Punctaporonins H–M: Caryophyllene-Type Sesquiterpenoids from the Sponge-Associated Fungus Hansfordia sinuosae
by Zehong Wu, Dong Liu, Peter Proksch, Peng Guo and Wenhan Lin
Mar. Drugs 2014, 12(7), 3904-3916; https://doi.org/10.3390/md12073904 - 30 Jun 2014
Cited by 41 | Viewed by 8467
Abstract
Six new caryophyllene-based sesquiterpenoids named punctaporonins H–M (16), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. Their structures were determined by the [...] Read more.
Six new caryophyllene-based sesquiterpenoids named punctaporonins H–M (16), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. Their structures were determined by the extensive HRESIMS and NMR spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of punctaporonins H–I (12). The isolated compounds were evaluated for antihyperlipidemic, cytotoxic and antimicrobial activities, and punctaporonin K (4) exhibited potent effects to reduce the triglycerides and total cholesterol in the intracellular levels. Full article
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