Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = F49A-FTP

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
16 pages, 734 KiB  
Review
HCMV Antivirals and Strategies to Target the Latent Reservoir
by Marianne R. Perera, Mark R. Wills and John H. Sinclair
Viruses 2021, 13(5), 817; https://doi.org/10.3390/v13050817 - 1 May 2021
Cited by 31 | Viewed by 5154
Abstract
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage. However, HCMV often causes severe disease in the immunosuppressed: transplant recipients [...] Read more.
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage. However, HCMV often causes severe disease in the immunosuppressed: transplant recipients and people living with AIDS, and also in the immunonaive foetus. At present, there are several antiviral drugs licensed to control HCMV disease. However, these are all faced with problems of poor bioavailability, toxicity and rapidly emerging viral resistance. Furthermore, none of them are capable of fully clearing the virus from the host, as they do not target latent infection. Consequently, reactivation from latency is a significant source of disease, and there remains an unmet need for treatments that also target latent infection. This review briefly summarises the most common HCMV antivirals used in clinic at present and discusses current research into targeting the latent HCMV reservoir. Full article
(This article belongs to the Special Issue New Concepts of Antiviral Strategies Against HCMV)
Show Figures

Figure 1

Back to TopTop