Two new amicoumacins, named Damxungmacin A (
1) and B (
2), were isolated from the culture broth of a soil-derived bacterium
Bacillus subtilis XZ-7. Their chemical structures were elucidated by spectroscopic studies (UV, IR, NMR and HR-ESI-MS). Compound
1 possessed
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Two new amicoumacins, named Damxungmacin A (
1) and B (
2), were isolated from the culture broth of a soil-derived bacterium
Bacillus subtilis XZ-7. Their chemical structures were elucidated by spectroscopic studies (UV, IR, NMR and HR-ESI-MS). Compound
1 possessed a 1,4-diazabicyclo[2.2.1]heptane-2-one ring system in its structure, which was reported for the first time, while
2 had a 1-acetylmorpholine-3-one moiety, which was naturally rare. Compound
1 exhibited moderate to weak cytotoxic activities against three human tumor cell lines (A549, HCT116 and HepG2) with IC
50 values of 13.33, 14.34 and 13.64 μM, respectively. Meanwhile, compound
1 showed weak antibacterial activities against some strains of
Staphylococcus epidermidis, while compound
2 at 16 μg/mL did not show antibacterial activity.
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