Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 

Saved Queries

Sign in to use this feature.

Search Filter Reset All

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
Add Subjects Reset
Select Subjects

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
Add Journals Reset
Select Journals

Article Types

remove_circle_outline
Add Article Types Reset
Select Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
Add Countries / Regions Reset
Select Countries / Regions
Update Search
share announcement

Search Results (3)

Search Parameters:
Keywords = DIBOA (2,4-dihydroxy-1,4-benzoxazin-3-one)

Order results
Result details
Results per page
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
16 pages, 5047 KiB  
Article
Acanthus mollis Formulations for Transdermal Delivery: From Hydrogels to Emulsions
by Patrícia Matos, Maria Teresa Batista, Francisco Veiga, Artur Figueirinha and Ana Figueiras
Gels 2024, 10(1), 36; https://doi.org/10.3390/gels10010036 - 31 Dec 2023
Cited by 4 | Viewed by 2231
Abstract
Topical formulations of Acanthus mollis L. leaf and the optimization of the release of their active compounds and their topical bioavailability were investigated for the first time. In vitro, the release of active compounds from three formulations—an oil-in-water cream and two hydrogels (Carbopol [...] Read more.
Topical formulations of Acanthus mollis L. leaf and the optimization of the release of their active compounds and their topical bioavailability were investigated for the first time. In vitro, the release of active compounds from three formulations—an oil-in-water cream and two hydrogels (Carbopol 940 and Pluronic F-127)—was determined using Franz diffusion cells. Detection and quantification of the compounds was performed via high-performance liquid chromatography with a photodiode array (HPLC-PDA). DIBOA, a bioactive compound of this medicinal plant, exhibited release kinetics of the Weibull model for the Carbopol and Pluronic F-127 formulation, identifying it as a potential active agent to optimize the topical distribution of the formulations. The implications extend to applications in inflammation treatment and tyrosinase inhibition, suggesting that it can make a significant contribution to addressing skin conditions, including melanoma and various inflammatory diseases. Full article
(This article belongs to the Special Issue Gel-Based Drug Delivery Systems for Cancer Treatment)
►▼ Show Figures

Figure 1

16 pages, 1193 KiB  
Article
Synergistic Effect of DIBOA and Verbascoside from Acanthus mollis Leaf on Tyrosinase Inhibition
by Patrícia Matos, António Paranhos, Maria Teresa Batista and Artur Figueirinha
Int. J. Mol. Sci. 2022, 23(21), 13536; https://doi.org/10.3390/ijms232113536 - 4 Nov 2022
Cited by 14 | Viewed by 2456
Abstract
Overexpression of melanin contributes to darkening of plant and fruit tissues and skin hyperpigmentation, leading to melasma or age spots. Although melanin biosynthesis is complex and involves several steps, a single enzyme known as tyrosinase is key to regulating this process. The melanogenesis [...] Read more.
Overexpression of melanin contributes to darkening of plant and fruit tissues and skin hyperpigmentation, leading to melasma or age spots. Although melanin biosynthesis is complex and involves several steps, a single enzyme known as tyrosinase is key to regulating this process. The melanogenesis pathway is initiated by oxidation of the starting material l-tyrosine (or l-DOPA) to dopaquinone by tyrosinase; the resulting quinone then serves as a substrate for subsequent steps that eventually lead to production of melanin. Medicinal plants are considered a good source of tyrosinase inhibitors. This study investigated the tyrosinase inhibitory activity of A. mollis leaf extracts and their phytochemicals. Significant activity was verified in the ethanol extract –EEt (IC50 = 1.21 µg/mL). Additionally, a kinetic study showed that this tyrosinase inhibition occurs by DIBOA (2,4-dihydroxy-1,4-benzoxazin-3-one) and verbascoside contribution through a non-competitive reaction mechanism. A synergistic effect on tyrosinase inhibition was observed in the binary combination of the compounds. In conclusion, both EEt and a mixture of two of its phytochemicals can be effective tyrosinase inhibitors and can be used as a bleaching agent for cosmetic formulations in the future. Full article
(This article belongs to the Special Issue Biological Properties of Medicinal Plants)
►▼ Show Figures

Figure 1

6 pages, 2007 KiB  
Article
Completion of the Spectroscopical Data for the Synthesis of DIMBOA
by Norbert Handler and Thomas Erker
Sci. Pharm. 2005, 73(3), 95-100; https://doi.org/10.3797/scipharm.aut-05-08 - 30 Sep 2005
Cited by 2 | Viewed by 1422
Abstract
Cyclic hydroxamic acids like 2,4-dihydroxy-7-methoxy-2H-1 ,4-benzoxazin-3(4H)-one (DIM BOA) and 2,4-dihydroxy-2H-1 ,4-benzoxazin-3(4H)-one (DIBOA) are found in several plants playing an important role in the defense-system of plants against a variety of enemies. To investigate new mechanism and effects we synthesized the molecules using known [...] Read more.
Cyclic hydroxamic acids like 2,4-dihydroxy-7-methoxy-2H-1 ,4-benzoxazin-3(4H)-one (DIM BOA) and 2,4-dihydroxy-2H-1 ,4-benzoxazin-3(4H)-one (DIBOA) are found in several plants playing an important role in the defense-system of plants against a variety of enemies. To investigate new mechanism and effects we synthesized the molecules using known synthetic pathways. Since the chemical data of DIMBOA are not complete or even false, we decided to publish the missing ones in this journal. Full article
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying article 1-50 on page 1 of 1.
Back to TopTop