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Keywords = Cytospora heveae

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10 pages, 542 KiB  
Article
Antioxidative Indenone and Benzophenone Derivatives from the Mangrove-Derived Fungus Cytospora heveae NSHSJ-2
by Ge Zou, Taobo Li, Wencong Yang, Bing Sun, Yan Chen, Bo Wang, Yanghui Ou, Huijuan Yu and Zhigang She
Mar. Drugs 2023, 21(3), 181; https://doi.org/10.3390/md21030181 - 14 Mar 2023
Cited by 9 | Viewed by 2569
Abstract
Seven new polyketides, including four indenone derivatives, cytoindenones A–C (1, 34), 3′-methoxycytoindenone A (2), a benzophenone derivative, cytorhizophin J (6), and a pair of tetralone enantiomers, (±)-4,6-dihydroxy-5-methoxy-α-tetralone (7), together with [...] Read more.
Seven new polyketides, including four indenone derivatives, cytoindenones A–C (1, 34), 3′-methoxycytoindenone A (2), a benzophenone derivative, cytorhizophin J (6), and a pair of tetralone enantiomers, (±)-4,6-dihydroxy-5-methoxy-α-tetralone (7), together with a known compound (5) were obtained from the endophytic fungus Cytospora heveae NSHSJ-2 isolated from the fresh stem of the mangrove plant Sonneratia caseolaris. Compound 3 represented the first natural indenone monomer substituted by two benzene moieties at C-2 and C-3. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data, and the absolute configurations of (±)-7 were determined on the basis of the observed specific rotation value compared with those of the tetralone derivatives previously reported. In bioactivity assays, compounds 1, 46 showed potent DPPH· scavenging activities, with EC50 values ranging from 9.5 to 16.6 µM, better than the positive control ascorbic acid (21.9 µM); compounds 23 also exhibited DPPH· scavenging activities comparable to ascorbic acid. Full article
(This article belongs to the Special Issue Pharmacological Potential of Marine Natural Products)
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