The aim of this work was to comprehensively understand the chemical constituents of the edible mushroom
Craterellus ordoratus and their bioactivity. A chemical investigation on this mushroom led to the isolation of 23 sesquiterpenoids including eighteen previously undescribed bergamotane sesquiterpenes, craterodoratins A–R (
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The aim of this work was to comprehensively understand the chemical constituents of the edible mushroom
Craterellus ordoratus and their bioactivity. A chemical investigation on this mushroom led to the isolation of 23 sesquiterpenoids including eighteen previously undescribed bergamotane sesquiterpenes, craterodoratins A–R (
1–
18), and one new victoxinine derivative, craterodoratin S (
19). The new structures were elucidated by detailed interpretation of spectrometric data, theoretical nuclear magnetic resonance (NMR) and electronic circular dichroism (ECD) calculations, and single-crystal X-ray crystallographic analysis. Compounds
1 and
2 possess a ring-rearranged carbon skeleton. Compounds
3,
10,
12–
15,
19,
20 and
23 exhibit potent inhibitory activity against the lipopolysaccharide (LPS)-induced proliferation of B lymphocyte cells with the IC
50 values ranging from 0.67 to 22.68 μM. Compounds
17 and
20 inhibit the concanavalin A (ConA)-induced proliferation of T lymphocyte cell with IC
50 values of 31.50 and 0.98 μM, respectively. It is suggested that
C. ordoratus is a good source for bergamotane sesquiterpenoids, and their immunosuppressive activity was reported for the first time. This research is conducive to the further development and utilization of
C. ordoratus.
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