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Keywords = Aspergillus austwickii SCSIO41227

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12 pages, 1985 KiB  
Article
Secondary Metabolites from the Coral-Derived Fungus Aspergillus austwickii SCSIO41227 with Pancreatic Lipase and Neuraminidase Inhibitory Activities
by Ying Chen, Yanchun He, Xiaoyan Pang, Xuefeng Zhou, Yonghong Liu and Bin Yang
Mar. Drugs 2023, 21(11), 567; https://doi.org/10.3390/md21110567 - 29 Oct 2023
Cited by 5 | Viewed by 2190
Abstract
The coral-derived fungus Aspergillus austwickii SCSIO41227 from Beibu Gulf yielded four previously uncharacterized compounds, namely asperpentenones B–E (14), along with twelve known compounds (516). Their structures were elucidated using HRESIMS and NMR (1H [...] Read more.
The coral-derived fungus Aspergillus austwickii SCSIO41227 from Beibu Gulf yielded four previously uncharacterized compounds, namely asperpentenones B–E (14), along with twelve known compounds (516). Their structures were elucidated using HRESIMS and NMR (1H and 13C NMR, HSQC, HMBC), among which the stereo-structure of compounds 13 was determined by calculated ECD. Furthermore, compounds 116 were evaluated in terms of their enzyme (acetylcholinesterase (AChE), pancreatic lipase (PL), and neuraminidase (NA)) inhibitory activities. These bioassay results revealed that compounds 2 and 14 exerted noticeable NA inhibitory effects, with IC50 values of 31.28 and 73.64 μM, respectively. In addition, compound 3 exhibited a weak inhibitory effect against PL. Furthermore, these compounds showed the potential of inhibiting enzymes in silico docking analysis to demonstrate the interactions between compounds and proteins. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites of Marine Fungi 2.0)
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