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Keywords = Acalypha monostachya

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23 pages, 6528 KiB  
Article
Cytotoxic Effect In Vitro of Acalypha monostachya Extracts over Human Tumor Cell Lines
by Gloria A. Guillén-Meléndez, Sheila A. Villa-Cedillo, Raymundo A. Pérez-Hernández, Uziel Castillo-Velázquez, Daniel Salas-Treviño, Odila Saucedo-Cárdenas, Roberto Montes-de-Oca-Luna, Christian A. Gómez-Tristán, Aimé Jazmín Garza-Arredondo, Diana Elisa Zamora-Ávila, María de Jesús Loera-Arias and Adolfo Soto-Domínguez
Plants 2021, 10(11), 2326; https://doi.org/10.3390/plants10112326 - 28 Oct 2021
Cited by 13 | Viewed by 3747
Abstract
Acalypha monostachya (A. monostachya) is a plant that is used in traditional medicine as a cancer treatment; however, its effect has not been validated. In this study, the potential cytotoxic effects and morphological changes of A. monostachya were evaluated in human tumor cell [...] Read more.
Acalypha monostachya (A. monostachya) is a plant that is used in traditional medicine as a cancer treatment; however, its effect has not been validated. In this study, the potential cytotoxic effects and morphological changes of A. monostachya were evaluated in human tumor cell lines. The aqueous (AE), methanolic (ME), and hexane (HE) extracts were obtained, and flavonoid-type phenolic compounds were detected, which indicates an antineoplastic effect. We observed a time-dependent and concentration-selective toxicity in human tumor cells. Additionally, the ME and HE showed the greatest cytotoxic effect at minimum concentrations compared to the AE, which showed this effect at the highest concentrations. All extracts induced significant morphological changes in tumor cells. The HeLa (cervix carcinoma) cells were more sensitive compared to the MDA-MB-231 (triple-negative breast cancer) cells. In conclusion, we demonstrated a cytotoxic in vitro effect of A. monostachya extracts in tumoral human cell lines. These results show the potential antineoplastic effects of A. monostachya in vitro. Hereafter, our lab team will continue working to usefully isolate and obtain the specific compounds of A. monostachya extracts with cytotoxic effects on tumor cells to find more alternatives for cancer treatment. Full article
(This article belongs to the Special Issue Plant Therapeutics)
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