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Keywords = ACDHUVV-16

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15 pages, 331 KiB  
Review
Heart Failure after Cardiac Surgery: The Role of Halogenated Agents, Myocardial Conditioning and Oxidative Stress
by José Luis Guerrero-Orriach, Maria Dolores Carmona-Luque and Laura Gonzalez-Alvarez
Int. J. Mol. Sci. 2022, 23(3), 1360; https://doi.org/10.3390/ijms23031360 - 25 Jan 2022
Cited by 15 | Viewed by 4085
Abstract
Heart disease requires a surgical approach sometimes. Cardiac-surgery patients develop heart failure associated with ischemia induced during extracorporeal circulation. This complication could be decreased with anesthetic drugs. The cardioprotective effects of halogenated agents are based on pre- and postconditioning (sevoflurane, desflurane, or isoflurane) [...] Read more.
Heart disease requires a surgical approach sometimes. Cardiac-surgery patients develop heart failure associated with ischemia induced during extracorporeal circulation. This complication could be decreased with anesthetic drugs. The cardioprotective effects of halogenated agents are based on pre- and postconditioning (sevoflurane, desflurane, or isoflurane) compared to intravenous hypnotics (propofol). We tried to put light on the shadows walking through the line of the halogenated anesthetic drugs’ effects in several enzymatic routes and oxidative stress, waiting for the final results of the ACDHUVV-16 clinical trial regarding the genetic modulation of this kind of drugs. Full article
(This article belongs to the Special Issue Metabolic Therapies for Heart Failure)
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