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Keywords = 5-sulfosalicylic acid iodination

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12 pages, 3861 KB  
Article
Electrochemical Iodination through the In Situ Generation of Iodinating Agents: A Promising Green Approach
by Letizia Sorti, Fiammetta Vitulano, Elia Cappellini, Fulvio Uggeri, Carlo Francesco Morelli, Guido Sello, Alessandro Minguzzi and Alberto Vertova
Molecules 2023, 28(14), 5555; https://doi.org/10.3390/molecules28145555 - 20 Jul 2023
Cited by 5 | Viewed by 3886
Abstract
The synthesis of iodinated compounds using cheap, simple, and green strategies is of fundamental importance. Iodination reactions are mainly used to synthesize useful intermediates, especially in the pharmaceutical field, where they are employed for the production of contrast media or of iodinated active [...] Read more.
The synthesis of iodinated compounds using cheap, simple, and green strategies is of fundamental importance. Iodination reactions are mainly used to synthesize useful intermediates, especially in the pharmaceutical field, where they are employed for the production of contrast media or of iodinated active pharmaceutical ingredients. Traditional synthetic methods suffer from the use of erosive, toxic, or hazardous reactants. Approaches which involve the use of molecular iodine as an iodinating agent require the addition of an oxidizing agent, which is often difficult to handle. Electrochemistry can offer a valid and green alternative by avoiding the addition of such oxidizing agents, transforming the iodine source in the active species through the use of electrons as the main reactants. Herein, we report the electrochemical iodination with the generation of iodinating species in situ in water by using iodides as the source of iodine atoms. First of all, the electrochemical behavior of iodide and iodine in water on carbonaceous anodes was studied and, after selecting the suitable potential, in situ electrochemical iodination was successfully applied to 5-hydroxyisophthalic acid and 5-sulfosalicylic acid, comparing the iodinating power of I2 and iodonium species. Full article
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