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Keywords = 4-amino-4-deoxychorismate synthase inhibitor

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9 pages, 2280 KiB  
Review
Abyssomicins—A 20-Year Retrospective View
by Hans-Peter Fiedler
Mar. Drugs 2021, 19(6), 299; https://doi.org/10.3390/md19060299 - 24 May 2021
Cited by 14 | Viewed by 3490
Abstract
Abyssomicins represent a new family of polycyclic macrolactones. The first described compounds of the abyssomicin family were abyssomicin B, C, atrop-C, and D, produced by the marine actinomycete strain Verrucosispora maris AB-18-032, which was isolated from a sediment collected in the Sea of [...] Read more.
Abyssomicins represent a new family of polycyclic macrolactones. The first described compounds of the abyssomicin family were abyssomicin B, C, atrop-C, and D, produced by the marine actinomycete strain Verrucosispora maris AB-18-032, which was isolated from a sediment collected in the Sea of Japan. Among the described abyssomicins, only abyssomicin C and atrop-abyssomicin C show a high antibiotic activity against Gram-positive bacteria, including multi-resistant and vancomycin-resistant strains. The inhibitory activity is caused by a selective inhibition of the enzyme 4-amino-4-deoxychorismate synthase, which catalyzes the transformation of chorismate to para-aminobenzoic acid, an intermediate in the folic acid pathway. Full article
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