Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = 3-indoleacetonitrile

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
13 pages, 3147 KiB  
Article
3-Indoleacetonitrile Is Highly Effective in Treating Influenza A Virus Infection In Vitro and In Vivo
by Xuejin Zhao, Lianzhong Zhao, Ya Zhao, Kun Huang, Wenxiao Gong, Ying Yang, Li Zhao, Xiaohan Xia, Zaiyun Li, Feng Sheng, Xuezhu Du and Meilin Jin
Viruses 2021, 13(8), 1433; https://doi.org/10.3390/v13081433 - 23 Jul 2021
Cited by 19 | Viewed by 3463
Abstract
Influenza A viruses are serious zoonotic pathogens that continuously cause pandemics in several animal hosts, including birds, pigs, and humans. Indole derivatives containing an indole core framework have been extensively studied and developed to prevent and/or treat viral infection. This study evaluated the [...] Read more.
Influenza A viruses are serious zoonotic pathogens that continuously cause pandemics in several animal hosts, including birds, pigs, and humans. Indole derivatives containing an indole core framework have been extensively studied and developed to prevent and/or treat viral infection. This study evaluated the anti-influenza activity of several indole derivatives, including 3-indoleacetonitrile, indole-3-carboxaldehyde, 3-carboxyindole, and gramine, in A549 and MDCK cells. Among these compounds, 3-indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, as tested in A549 cells. Importantly, in a mouse model, 3-indoleacetonitrile with a non-toxic concentration of 20 mg/kg effectively reduced the mortality and weight loss, diminished lung virus titers, and alleviated lung lesions of mice lethally challenged with A/duck/Hubei/WH18/2015 H5N6 and A/Puerto Rico/8/1934 H1N1 influenza A viruses. The antiviral properties enable the potential use of 3-indoleacetonitrile for the treatment of IAV infection. Full article
(This article belongs to the Topic Broad-Spectrum Antiviral Agents)
Show Figures

Figure 1

Back to TopTop