Condensation of 3-acetyl-8-ethoxycoumarin (
3) with thiosemicarbazide gave ethylidenehydrazinecarbothioamide
5, which was transformed into the thiazolidin-4-one derivatives
6,
7. Interaction of
3 with DMF/POCl
3 gave
b-chloroacroline derivative
8. Treatment of
3 with malononitrile gave benzo[
c
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Condensation of 3-acetyl-8-ethoxycoumarin (
3) with thiosemicarbazide gave ethylidenehydrazinecarbothioamide
5, which was transformed into the thiazolidin-4-one derivatives
6,
7. Interaction of
3 with DMF/POCl
3 gave
b-chloroacroline derivative
8. Treatment of
3 with malononitrile gave benzo[
c]chromone and 2-aminobenzonitrile derivatives
9 and
10, respectively with respect to the reaction conditions. Condensation of 3-(2-bromoacetyl)-8-ethoxycoumarin (
4) with
o-phenylenediamine gave 3-(quioxaline-2-yl)-8-ethoxycoumarin hydrobromide (
11), while
4 reacted with 2-aminopyridine to give chromenopyridopyrimidine derivative
12. Condensation of
4 with potassium thio-cyanate/methanol gave an unexpected derivative, 2
H-chromeno-3-carboxy(methyl-carbonimidic)thioanhydride
16, which upon treatment with (NH
2)
2·H
2O gave 3-ethoxy-2-hydroxybenzaldehyde azine
19. Interaction of
4 with thiourea derivatives gave thiazole derivatives
20a–c. The structures of the newly synthesized compounds were confirmed by their spectra data. The newly synthesized compounds were also screened for their antimicrobial activity.
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