Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (2)

Search Parameters:
Keywords = 3α-hydroxy-masticadienoic acid

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
14 pages, 1993 KiB  
Article
1H Nuclear Magnetic Resonance-Based Targeted and Untargeted Metabolomics Profiling of Retail Samples of Cuachalalate (Amphipterygium adstringens)
by Erick Alejandro Herrera-Jurado, Estefanía De Jesús Terán-Sánchez, José Iván Serrano-Contreras and L. Gerardo Zepeda-Vallejo
Molecules 2025, 30(10), 2185; https://doi.org/10.3390/molecules30102185 - 16 May 2025
Cited by 1 | Viewed by 884
Abstract
Amphipterygium adstringens (cuachalalate) is a medicinal plant widely used in traditional Mexican medicine for its anti-inflammatory, gastroprotective, and antimicrobial properties. In this study, we applied qualitative and quantitative NMR-based metabolomics profiling, combined with multivariate statistical analyses, including Principal Component Analysis (PCA), Partial Least [...] Read more.
Amphipterygium adstringens (cuachalalate) is a medicinal plant widely used in traditional Mexican medicine for its anti-inflammatory, gastroprotective, and antimicrobial properties. In this study, we applied qualitative and quantitative NMR-based metabolomics profiling, combined with multivariate statistical analyses, including Principal Component Analysis (PCA), Partial Least Squares Discriminant Analysis (PLS-DA), and S-plots, to evaluate the chemical composition and authenticity of A. adstringens samples collected from different commercial sources sold in Mexico City. Metabolomic profiles in organic and aqueous extracts revealed highly similar spectral patterns among all collected samples, supporting the consistency of commercially available A. adstringens in Mexico. The presence of 3α-hydroxy-masticadienoic acid (3α-HMDA) and anacardic acids, biomarkers of the genus, was confirmed by 1H NMR in hexane extracts; in the aqueous extract they were not observed with the same analytical platform. These findings suggest that the traditional infusion method may not effectively extract the above-mentioned key bioactive compounds. This approach enhances quality control and ensures the reliability of A. adstringens products in the commercial market. Full article
Show Figures

Figure 1

12 pages, 22396 KiB  
Article
Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells
by Gabriela Piñón-Zárate, Fernanda Reyes-Riquelme, Ma Beatriz Sánchez-Monroy, Mónica Velasco-Torrez, Mariano Martínez-Vázquez, Christian Adrian Cárdenas-Monroy, Beatriz Hernandez-Téllez, Katia Jarquín-Yáñez, Miguel Ángel Herrera-Enríquez and Andrés Eliú Castell-Rodríguez
Molecules 2022, 27(4), 1451; https://doi.org/10.3390/molecules27041451 - 21 Feb 2022
Cited by 6 | Viewed by 3028
Abstract
Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate [...] Read more.
Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate DCs in situ or in vitro, with toxic effects. It has been shown that some molecules affect the immune system, e.g., Masticadienonic acid (MDA) and 3α-hydroxy masticadienoic acid (3α-OH MDA) triterpenes naturally occurring in several medicinal plants, since they activate the nitric oxide synthase in macrophages and induce T lymphocyte proliferation. The DCs maturation induced by MDA or 3a-OH MDA was determined by incubating these cells with MDA or 3α-OH MDA, and their phenotype was afterwards analyzed. The results showed that only 3α-OH MDA was able to induce DCs maturation. When mice with melanoma were inoculated with DCs/3α-OH MDA, a decreased tumor growth rate was observed along with an extended cell death area within tumors compared to mice treated with DCs incubated with MDA. In conclusion, it is proposed that 3α-OH MDA may be an immunostimulant molecule. Conversely, it is proposed that MDA may be a molecule with anti-inflammatory properties. Full article
Show Figures

Graphical abstract

Back to TopTop