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Keywords = 3,4-dimethoxybenzenamine Schiff bases

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20 pages, 699 KiB  
Article
Synthesis, Crystal Structure, DFT Studies and Evaluation of the Antioxidant Activity of 3,4-Dimethoxybenzenamine Schiff Bases
by Ahmad Nazif Aziz, Muhammad Taha, Nor Hadiani Ismail, El Hassane Anouar, Sammer Yousuf, Waqas Jamil, Khalijah Awang, Norizan Ahmat, Khalid M. Khan and Syed Muhammad Kashif
Molecules 2014, 19(6), 8414-8433; https://doi.org/10.3390/molecules19068414 - 19 Jun 2014
Cited by 49 | Viewed by 8610
Abstract
Schiff bases of 3,4-dimethoxybenzenamine 125 were synthesized and evaluated for their antioxidant activity. All the synthesized compounds were characterized by various spectroscopic techniques. In addition, the characterizations of compounds 13, 15 and 16 were supported by crystal X-ray determinations and [...] Read more.
Schiff bases of 3,4-dimethoxybenzenamine 125 were synthesized and evaluated for their antioxidant activity. All the synthesized compounds were characterized by various spectroscopic techniques. In addition, the characterizations of compounds 13, 15 and 16 were supported by crystal X-ray determinations and their geometrical parameters were compared with theoretical DFT calculations at the B3LYP level of theory. Furthermore, the X-ray crystal data of two non-crystalline compounds 8 and 18 were theoretically calculated and compared with the practical values of compounds 13, 15, 16 and found a good agreement. The compounds showed good DPPH scavenging activity ranging from 10.12 to 84.34 μM where compounds 14 and 6 showed stronger activity than the standard n-propyl gallate. For the superoxide anion radical assay, compounds 13 showed better activity than the standard. Full article
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