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Keywords = 2-(2-phenylethyl)chromone-sesquiterpene hybrids

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13 pages, 2498 KB  
Article
2-(2-Phenylethyl)chromone-Sesquiterpene Hybrids from Agarwood of Aquilaria sinensis: Characterization and Biological Activity Evaluation
by Guan-Hua Xu, Ya-Li Wang, Hao Wang, Hui-Qin Chen, Wen-Hua Dong, Sheng-Zhuo Huang, Cai-Hong Cai, Jing-Zhe Yuan, Wen-Li Mei, Shou-Bai Liu and Hao-Fu Dai
Molecules 2025, 30(9), 1984; https://doi.org/10.3390/molecules30091984 - 29 Apr 2025
Cited by 1 | Viewed by 1308
Abstract
Aquisinenins G–I (13), three new 2-(2-phenylethyl)chromone-sesquiterpene hybrids, were isolated from the ethanol extract of Hainan agarwood derived from Aquilaria sinensis. Spectroscopic techniques, such as 1D and 2D NMR and HRESIMS, were used to determine their structures. [...] Read more.
Aquisinenins G–I (13), three new 2-(2-phenylethyl)chromone-sesquiterpene hybrids, were isolated from the ethanol extract of Hainan agarwood derived from Aquilaria sinensis. Spectroscopic techniques, such as 1D and 2D NMR and HRESIMS, were used to determine their structures. Experimental and computed ECD data were compared to confirm their absolute configurations. Compounds 13 are uncommon dimeric derivatives of 2-(2-phenylethyl)chromone-sesquiterpene, characterized by the fusion of 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone with agarofuran or agarospirane-type sesquiterpene units by an ester linkage. Compound 1 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells, showing an IC50 value of 22.31 ± 0.42 μM. The neuroprotective effects of compounds 1 and 3 against H2O2-induced apoptosis were assessed in human neuroblastoma SH-SY5Y cells. Compound 1 demonstrated cytotoxicity with IC50 values of 72.37 ± 0.20 μM against K562 and 61.47 ± 0.22 μM against BEL-7402, while compounds 2 and 3 showed cytotoxicity across all five tested human cancer cell lines. Full article
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