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Keywords = δβ TCR

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26 pages, 3551 KiB  
Review
TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers
by Christopher Szeto, Christian A. Lobos, Andrea T. Nguyen and Stephanie Gras
Int. J. Mol. Sci. 2021, 22(1), 68; https://doi.org/10.3390/ijms22010068 - 23 Dec 2020
Cited by 115 | Viewed by 13314
Abstract
T cells are a critical part of the adaptive immune system that are able to distinguish between healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T cells will contribute to the immune response and help clear infection. The major histocompatibility [...] Read more.
T cells are a critical part of the adaptive immune system that are able to distinguish between healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T cells will contribute to the immune response and help clear infection. The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). This recognition event is the first step that leads to T cell activation, and in turn can dictate disease outcomes. The visualisation of TCR interaction with pMHC using structural biology has been crucial in understanding this key event, unravelling the parameters that drive this interaction and their impact on the immune response. The last five years has been the most productive within the field, wherein half of current unique TCR–pMHC-I structures to date were determined within this time. Here, we review the new insights learned from these recent TCR–pMHC-I structures and their impact on T cell activation. Full article
(This article belongs to the Special Issue Recent Advances in T Cell Immunity)
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