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Keywords = γ-halocarbanions

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20 pages, 6566 KiB  
Review
Chlorine in an Organic Molecule, a Universal Promoter—Workhorse—Of Reactions
by Mieczysław Mąkosza and Michał Fedoryński
Molecules 2023, 28(24), 7957; https://doi.org/10.3390/molecules28247957 - 5 Dec 2023
Cited by 2 | Viewed by 2979
Abstract
Due to the electronic configuration of the atom and charge of the nucleus, the chlorine in organic molecules can exert a variety of effects. It can depart as a chloride anion in the process of substitution and elimination, facilitates the abstraction of protons [...] Read more.
Due to the electronic configuration of the atom and charge of the nucleus, the chlorine in organic molecules can exert a variety of effects. It can depart as a chloride anion in the process of substitution and elimination, facilitates the abstraction of protons and stabilizes generated carbanions, exerts moderate stabilizing effect of carbenes, carbocations and radicals. There are frequent cases where chlorine substituent promotes more than one transformation. These rich effects of chlorine substituent will be illustrated by examples of our work. Full article
(This article belongs to the Special Issue Featured Reviews in Organic Chemistry 2024)
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