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Keywords = (di)amidophosphate

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28 pages, 14310 KiB  
Review
Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water
by Megha Karki, Clémentine Gibard, Subhendu Bhowmik and Ramanarayanan Krishnamurthy
Life 2017, 7(3), 32; https://doi.org/10.3390/life7030032 - 29 Jul 2017
Cited by 43 | Viewed by 12825
Abstract
Phosphorylation under plausible prebiotic conditions continues to be one of the defining issues for the role of phosphorus in the origins of life processes. In this review, we cover the reactions of alternative forms of phosphate, specifically the nitrogenous versions of phosphate (and [...] Read more.
Phosphorylation under plausible prebiotic conditions continues to be one of the defining issues for the role of phosphorus in the origins of life processes. In this review, we cover the reactions of alternative forms of phosphate, specifically the nitrogenous versions of phosphate (and other forms of reduced phosphorus species) from a prebiotic, synthetic organic and biochemistry perspective. The ease with which such amidophosphates or phosphoramidate derivatives phosphorylate a wide variety of substrates suggests that alternative forms of phosphate could have played a role in overcoming the “phosphorylation in water problem”. We submit that serious consideration should be given to the search for primordial sources of nitrogenous versions of phosphate and other versions of phosphorus. Full article
(This article belongs to the Special Issue Phosphorus (P) and the Origins of Life)
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