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Authors = Yara Mohsen

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37 pages, 1556 KiB  
Review
Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
by Jayaseelan Murugaiyan, P. Anand Kumar, G. Srinivasa Rao, Katia Iskandar, Stephen Hawser, John P. Hays, Yara Mohsen, Saranya Adukkadukkam, Wireko Andrew Awuah, Ruiz Alvarez Maria Jose, Nanono Sylvia, Esther Patience Nansubuga, Bruno Tilocca, Paola Roncada, Natalia Roson-Calero, Javier Moreno-Morales, Rohul Amin, Ballamoole Krishna Kumar, Abishek Kumar, Abdul-Rahman Toufik, Thaint Nadi Zaw, Oluwatosin O. Akinwotu, Maneesh Paul Satyaseela and Maarten B. M. van Dongenadd Show full author list remove Hide full author list
Antibiotics 2022, 11(2), 200; https://doi.org/10.3390/antibiotics11020200 - 4 Feb 2022
Cited by 323 | Viewed by 39047
Abstract
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure [...] Read more.
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure of conventional, traditional antimicrobial therapy, in the past two decades, no novel class of antibiotics has been introduced. Consequently, several novel alternative strategies to combat these (multi-) drug-resistant infectious microorganisms have been identified. The purpose of this review is to gather and consider the strategies that are being applied or proposed as potential alternatives to traditional antibiotics. These strategies include combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods, and unconventional techniques, including the CRISPR-Cas system. These alternative strategies may have the potential to change the treatment of multi-drug-resistant pathogens in human clinical settings. Full article
(This article belongs to the Special Issue Alternative Approaches to Treating Antimicrobial Resistant Infections)
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