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Authors = Xiaonan Shan

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12 pages, 5174 KiB  
Article
Artemis as Predictive Biomarker of Responsiveness to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer
by Hai Liu, Runying Huang, Jingjing Shan, Xuyun Xie, Chongwei Wang, Peng Hu and Xiaonan Sun
Curr. Oncol. 2024, 31(1), 535-546; https://doi.org/10.3390/curroncol31010037 - 18 Jan 2024
Cited by 2 | Viewed by 2068
Abstract
The aim of this study was to identify Artemis as a predictive biomarker for guiding preoperative chemoradiotherapy in locally advanced rectal cancer. The resection specimens were collected from 50 patients with rectal cancer who underwent preoperative chemoradiotherapy. Artemis expression in biopsy tissues was [...] Read more.
The aim of this study was to identify Artemis as a predictive biomarker for guiding preoperative chemoradiotherapy in locally advanced rectal cancer. The resection specimens were collected from 50 patients with rectal cancer who underwent preoperative chemoradiotherapy. Artemis expression in biopsy tissues was evaluated using immunohistochemical staining according to the percentage of positively stained cells combined with staining intensity. Among the 50 patients, 36 (72%) had a weakly positive Artemis protein expression, 10 (20%) had a moderately positive expression, and 4 (8%) showed a strongly positive expression. The criteria of magnetic resonance imaging tumor regression grade (mrTRG) and pathological rectal cancer regression grade (RCRG) were used to assess the tumor response to chemoradiotherapy. Correlation analysis shows that there is a significant negative correlation between high Artemis immunoscore and treatment response (r = −0.532, p < 0.001). The results imply that high Artemis expression was associated with poor treatment response. Our study suggested a potential role of Artemis as a predictive biomarker of the tumor response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer. Full article
(This article belongs to the Special Issue Combination Therapy in Gastrointestinal Cancers)
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9 pages, 2482 KiB  
Article
Tunable, High-Power, Narrow-Linewidth Diode Laser for Potassium Alkali Metal Vapor Laser Pumping
by Jinliang Han, Jun Zhang, Xiaonan Shan, Yawei Zhang, Hangyu Peng, Li Qin and Lijun Wang
Crystals 2022, 12(11), 1675; https://doi.org/10.3390/cryst12111675 - 20 Nov 2022
Cited by 3 | Viewed by 2870
Abstract
This work proposes a method of compressing spectral linewidth and tuning the central wavelength of multiple high-power diode laser arrays in an external cavity feedback structure based on one volume Bragg grating (VBG). Through the combination of beam collimation and spatial beam technologies, [...] Read more.
This work proposes a method of compressing spectral linewidth and tuning the central wavelength of multiple high-power diode laser arrays in an external cavity feedback structure based on one volume Bragg grating (VBG). Through the combination of beam collimation and spatial beam technologies, a diode laser source producing 102.1 W at an operating current of 40 A is achieved. This laser source has a central wavelength of 766 nm and a narrow spectral linewidth of 0.164 nm. Moreover, a tuning central wavelength ranging from 776–766.231 nm is realized by precisely controlling the temperature of the VBG, and the locked central wavelength as a function of temperature shifts at the rate of approximately 0.0076 nm/°C. The results further prove that the smile under 1 μm can restrain the self-excitation effect of the emitting laser, which can influence the efficiency of the potassium alkali metal vapor laser pumping. Full article
(This article belongs to the Special Issue Frontiers of Semiconductor Lasers)
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26 pages, 4436 KiB  
Review
Processes of the Reliability and Degradation Mechanism of High-Power Semiconductor Lasers
by Yue Song, Zhiyong Lv, Jiaming Bai, Shen Niu, Zibo Wu, Li Qin, Yongyi Chen, Lei Liang, Yuxin Lei, Peng Jia, Xiaonan Shan and Lijun Wang
Crystals 2022, 12(6), 765; https://doi.org/10.3390/cryst12060765 - 26 May 2022
Cited by 27 | Viewed by 10239
Abstract
High-power semiconductor lasers have attracted widespread attention because of their small size, easy modulation, and high conversion efficiency. They play an important role in national economic construction and national defense construction, including free-space communication; industrial processing; and the medical, aerospace, and military fields, [...] Read more.
High-power semiconductor lasers have attracted widespread attention because of their small size, easy modulation, and high conversion efficiency. They play an important role in national economic construction and national defense construction, including free-space communication; industrial processing; and the medical, aerospace, and military fields, as well as other fields. The reliability of high-power semiconductor lasers is the key point of the application system. Higher reliability is sought in the military defense and aerospace fields in particular. Reliability testing and failure analysis help to improve the performance of high-power semiconductor lasers. This article provides a basis for understanding the reliability issues of semiconductor lasers across the whole supply chain. Firstly, it explains the failure modes and causes of failure in high-power semiconductor lasers; this article also summarizes the principles and application status of accelerated aging experiments and lifetime evaluation; it also introduces common techniques used for high-power semiconductor laser failure analysis, such as the electron beam-induced current (EBIC) technique and the optical beam-induced current (OBIC) technique, etc. Finally, methods used to improve the reliability of high-power semiconductor lasers are proposed in terms of the preparation process, reliability screening, and method application. Full article
(This article belongs to the Special Issue Frontiers of Semiconductor Lasers)
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