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Authors = Vanessa Allwardt

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27 pages, 3676 KiB  
Review
Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption
by Vanessa Allwardt, Alexander J. Ainscough, Priyalakshmi Viswanathan, Stacy D. Sherrod, John A. McLean, Malcolm Haddrick and Virginia Pensabene
Bioengineering 2020, 7(3), 112; https://doi.org/10.3390/bioengineering7030112 - 16 Sep 2020
Cited by 70 | Viewed by 13372
Abstract
Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed [...] Read more.
Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed for the successful adoption and acceptance of this technology. Areas for improvement include technological maturity, more robust validation of translational and predictive in vivo-like biology, and requirements of tighter quality standards for commercial viability. In this review, we reported on the consensus around existing challenges and necessary performance benchmarks that are required toward the broader adoption of OOACs in the next five years, and we defined a potential roadmap for future translational development of OOAC technology. We provided a clear snapshot of the current developmental stage of OOAC commercialization, including existing platforms, ancillary technologies, and tools required for the use of OOAC devices, and analyze their technology readiness levels. Using data gathered from OOAC developers and end-users, we identified prevalent challenges faced by the community, strategic trends and requirements driving OOAC technology development, and existing technological bottlenecks that could be outsourced or leveraged by active collaborations with academia. Full article
(This article belongs to the Special Issue Organs-on-Chips, Volume 2)
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