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Authors = Srividya Subramanian

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8 pages, 408 KiB  
Review
Long Non-Coding RNAs Regulating Immunity in Insects
by Valluri Satyavathi, Rupam Ghosh and Srividya Subramanian
Non-Coding RNA 2017, 3(1), 14; https://doi.org/10.3390/ncrna3010014 - 16 Mar 2017
Cited by 35 | Viewed by 6713
Abstract
Recent advances in modern technology have led to the understanding that not all genetic information is coded into protein and that the genomes of each and every organism including insects produce non-coding RNAs that can control different biological processes. Among RNAs identified in [...] Read more.
Recent advances in modern technology have led to the understanding that not all genetic information is coded into protein and that the genomes of each and every organism including insects produce non-coding RNAs that can control different biological processes. Among RNAs identified in the last decade, long non-coding RNAs (lncRNAs) represent a repertoire of a hidden layer of internal signals that can regulate gene expression in physiological, pathological, and immunological processes. Evidence shows the importance of lncRNAs in the regulation of host–pathogen interactions. In this review, an attempt has been made to view the role of lncRNAs regulating immune responses in insects. Full article
(This article belongs to the Section Long Non-Coding RNA)
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16 pages, 130 KiB  
Review
Clinical Toxicities of Histone Deacetylase Inhibitors
by Srividya Subramanian, Susan E. Bates, John J. Wright, Igor Espinoza-Delgado and Richard L. Piekarz
Pharmaceuticals 2010, 3(9), 2751-2767; https://doi.org/10.3390/ph3092751 - 26 Aug 2010
Cited by 295 | Viewed by 14153
Abstract
The HDAC inhibitors are a new family of antineoplastic agents. Since the entry of these agents into our therapeutic armamentarium, there has been increasing interest in their use. Although this family comprises chemical compounds from unrelated chemical classes that have different HDAC isoform [...] Read more.
The HDAC inhibitors are a new family of antineoplastic agents. Since the entry of these agents into our therapeutic armamentarium, there has been increasing interest in their use. Although this family comprises chemical compounds from unrelated chemical classes that have different HDAC isoform specificities, they surprisingly have very similar toxicity profiles. In contrast, the observed toxicity profile is somewhat different from that of traditional cytotoxic chemotherapeutic agents and from other epigenetic agents. While some of the side effects may be familiar to the oncologist, others are less commonly seen. As some patients remain on therapy for a prolonged period of time, the long-term sequelae need to be characterized. In addition, since preclinical models suggest promising activity when used in combination with other antineoplastic agents, combination trials are being pursued. It will thus be important to distinguish the relative toxicity attributed to these agents and be alert to the exacerbation of toxicities observed in single agent studies. Notably, few of the agents in this class have completed phase 2 testing. Consequently, more clinical experience is needed to determine the relative frequency of the observed side effects, and to identify and develop approaches to mitigate potential clinical sequelae. Full article
(This article belongs to the Special Issue HDAC Inhibitors)
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