Search Results (3)

Background: Although higher-generation TKIs are associated with improved progression-free survival in advanced NSCLC patients with EGFR mutations, the optimal selection of TKI treatment remains uncertain. To address this gap, we developed a web application powered by a reinforcement learning (RL) algorithm to assist in guiding initial TKI treatment decisions. Methods: Clinical and mutational data from advanced NSCLC patients were retrospectively collected from 14 medical centers. Only patients with complete data and sufficient follow-up were included. Multiple supervised machine learning models were tested, with the Extra Trees Classifier (ETC) identified as the most effective for predicting progression-free survival. Feature importance scores were calculated by the ETC, and features were then integrated into a Deep Q-Network (DQN) RL algorithm. The RL model was designed to select optimal TKI generation and a treatment line for each patient and was embedded into an open-source web application for experimental clinical use. Results: In total, 318 cases of EGFR-mutant advanced NSCLC were analyzed, with a median patient age of 63. A total of 52.2% of patients were female, and 83.3% had ECOG scores of 0 or 1. The top three most influential features identified were neutrophil-to-lymphocyte ratio (log-transformed), age (log-transformed), and the treatment line of TKI administration, as tested by the ETC algorithm, with an area under curve (AUC) value of 0.73, whereas the DQN RL algorithm achieved a higher AUC value of 0.80, assigning distinct Q-values across four TKI treatment categories. This supports the decision-making process in the web-based ‘EGFR Mutant NSCLC Treatment Advisory System’, where clinicians can input patient-specific data to receive tailored recommendations. Conclusions: The RL-based web application shows promise in assisting TKI treatment selection for EGFR-mutant advanced NSCLC patients, underscoring the potential for reinforcement learning to enhance decision-making in oncology care. Full article

Determining efficient solutions for large scale transportation problems is an important task in operations research. In this study, Vogel’s Approximation Method (VAM) which is one of well-known transportation methods in the literature was investigated to obtain more efficient initial solutions. A variant of VAM was proposed by using total opportunity cost and regarding alternative allocation costs. Computational experiments were carried out to evaluate VAM and improved version of VAM (IVAM). It was seen that IVAM conspicuously obtains more efficient initial solutions for large scale transportation problems. Performance of IVAM over VAM was discussed in terms of iteration numbers and CPU times required to reach the optimal solutions. Full article

The aim of study is developing a fuzzy decision model to select appropriate operating system for computer systems of the firms by taking subjective judgments of decision makers into consideration. Proposed approach is based on Fuzzy Analytic Hierarchy Process (FAHP) and TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) methods. FAHP method is used in determining the weights of the criteria by decision makers and then rankings of the operating systems are determined by TOPSIS method. Empirical study has also been demonstrated. Full article