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Authors = Satoshi Ohtake

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49 pages, 867 KiB  
Review
Developments and Challenges for mAb-Based Therapeutics
by Sumit Goswami, Wei Wang, Tsutomu Arakawa and Satoshi Ohtake
Antibodies 2013, 2(3), 452-500; https://doi.org/10.3390/antib2030452 - 16 Aug 2013
Cited by 123 | Viewed by 32551
Abstract
The continuous increase in the number of approved monoclonal antibody (mAb)-based therapy suggests that mAbs, and their derivatives, will continue to be the focus of the biotherapeutics industry for years to come. Although vast improvements in our capability to manufacture, characterize, and stabilize [...] Read more.
The continuous increase in the number of approved monoclonal antibody (mAb)-based therapy suggests that mAbs, and their derivatives, will continue to be the focus of the biotherapeutics industry for years to come. Although vast improvements in our capability to manufacture, characterize, and stabilize mAbs have been achieved, there are still challenges to be overcome. These include analytical and stabilization approaches associated with the development of high concentration mAb formulations. In addition, several mAb-based modalities are under development, including antibody drug conjugates (ADCs), fusion proteins, and bispecific antibodies (bsAbs), all designed to overcome the limitations encountered with mAb therapy. The current status of their development, with emphasis on manufacturing challenges as well as preliminary clinical results, will be reviewed. Full article
(This article belongs to the Special Issue Monoclonal Antibody Preparation against Natural Product and Its Application)
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17 pages, 512 KiB  
Review
Arginine as a Synergistic Virucidal Agent
by Satoshi Ohtake, Tsutomu Arakawa and A. Hajime Koyama
Molecules 2010, 15(3), 1408-1424; https://doi.org/10.3390/molecules15031408 - 8 Mar 2010
Cited by 11 | Viewed by 13106
Abstract
Development of effective and environmentally friendly disinfectants, or virucidal agents, should help prevent the spread of infectious diseases through human contact with contaminated surfaces. These agents may also be used, if non-toxic to cells and tissues, as chemotherapeutic agents against infectious diseases. We [...] Read more.
Development of effective and environmentally friendly disinfectants, or virucidal agents, should help prevent the spread of infectious diseases through human contact with contaminated surfaces. These agents may also be used, if non-toxic to cells and tissues, as chemotherapeutic agents against infectious diseases. We have shown that arginine has a synergistic effect with a variety of virucidal conditions, namely acidic pH and high temperature, on virus inactivation. All of these treatments are effective, however, at the expense of toxicity. The ability of arginine to lower the effective threshold of these parameters may reduce the occurrence of potential toxic side effects. While it is clear that arginine can be safely used, the mechanism of its virus inactivation has not yet been elucidated. Here we examine the damages that viruses suffer from various physical and chemical stresses and their relations to virus inactivation and aggregation. Based on the relationship between the stress-induced structural damages and the infectivity of a virus, we will propose several plausible mechanisms describing the effects of arginine on virus inactivation using the current knowledge of aqueous arginine solution properties. Full article
(This article belongs to the Special Issue Anti-Infective Agents)
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