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Authors = Sarah Djermoun

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32 pages, 1104 KiB  
Review
Plasmid Transfer by Conjugation in Gram-Negative Bacteria: From the Cellular to the Community Level
by Chloé Virolle, Kelly Goldlust, Sarah Djermoun, Sarah Bigot and Christian Lesterlin
Genes 2020, 11(11), 1239; https://doi.org/10.3390/genes11111239 - 22 Oct 2020
Cited by 197 | Viewed by 30882
Abstract
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer mechanism through which DNA is transferred from a donor to a recipient bacterium by direct contact. Conjugation is universally conserved among bacteria and occurs in a wide range of [...] Read more.
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer mechanism through which DNA is transferred from a donor to a recipient bacterium by direct contact. Conjugation is universally conserved among bacteria and occurs in a wide range of environments (soil, plant surfaces, water, sewage, biofilms, and host-associated bacterial communities). Within these habitats, conjugation drives the rapid evolution and adaptation of bacterial strains by mediating the propagation of various metabolic properties, including symbiotic lifestyle, virulence, biofilm formation, resistance to heavy metals, and, most importantly, resistance to antibiotics. These properties make conjugation a fundamentally important process, and it is thus the focus of extensive study. Here, we review the key steps of plasmid transfer by conjugation in Gram-negative bacteria, by following the life cycle of the F factor during its transfer from the donor to the recipient cell. We also discuss our current knowledge of the extent and impact of conjugation within an environmentally and clinically relevant bacterial habitat, bacterial biofilms. Full article
(This article belongs to the Special Issue Horizontal Gene Transfer in Bacteria)
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