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Authors = Rodrigo M. Feitosa ORCID = 0000-0001-9042-0129

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18 pages, 4724 KiB  
Article
BRAF, TERT and HLA-G Status in the Papillary Thyroid Carcinoma: A Clinicopathological Association Study
by Bruna C. Bertol, Juliana D. Massaro, Guilherme Debortoli, André L. P. Santos, Jéssica N. G. de Araújo, Tatiana M. V. Giorgenon, Matheus Costa e Silva, Nathalie L. de Figueiredo-Feitosa, Cristhianna V. A. Collares, Luiz Carlos C. de Freitas, Edson G. Soares, Luciano Neder, Vivian N. Silbiger, Rodrigo T. Calado, Léa M. Z. Maciel and Eduardo A. Donadi
Int. J. Mol. Sci. 2023, 24(15), 12459; https://doi.org/10.3390/ijms241512459 - 5 Aug 2023
Cited by 8 | Viewed by 2926
Abstract
As BRAF, TERT, HLA-G, and microRNAs have been individually associated with papillary thyroid carcinoma (PTC), we aimed to evaluate the individual and collaborative role of these markers in PTC in the same patient cohort. HLA-G and BRAF tumor expression was evaluated by immunohistochemistry. [...] Read more.
As BRAF, TERT, HLA-G, and microRNAs have been individually associated with papillary thyroid carcinoma (PTC), we aimed to evaluate the individual and collaborative role of these markers in PTC in the same patient cohort. HLA-G and BRAF tumor expression was evaluated by immunohistochemistry. Using molecular methods, BRAFV600E and TERT promoter mutations were evaluated in thyroid fine needle aspirates. MicroRNA tumor profiling was investigated using massively parallel sequencing. We observed strong HLA-G (67.96%) while BRAF (62.43%) staining was observed in PTC specimens. BRAF overexpression was associated with poor response to therapy. The BRAFV600E (52.9%) and TERTC228T (13%) mutations were associated with extrathyroidal extension, advanced-age, and advanced-stage cancer. The TERT rs2853669 CC+TC genotypes (38%) were overrepresented in metastatic tumors. Nine modulated microRNAs targeting the BRAF, TERT, and/or HLA-G genes were observed in PTC and involved with cancer-related signaling pathways. The markers were individually associated with PTC features, emphasizing the synergistic effect of BRAFV600E and TERTC228T; however, their collaborative role on PTC outcome was not fully demonstrated. The differentially expressed miRNAs targeting the BRAF and/or HLA-G genes may explain their increased expression in the tumor milieu. Full article
(This article belongs to the Special Issue Research Advances in Immunogenetics)
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21 pages, 1525 KiB  
Review
In Case of Fire, Escape or Die: A Trait-Based Approach for Identifying Animal Species Threatened by Fire
by Eugênia K. L. Batista, José E. C. Figueira, Ricardo R. C. Solar, Cristiano S. de Azevedo, Marina V. Beirão, Christian N. Berlinck, Reuber A. Brandão, Flávio S. de Castro, Henrique C. Costa, Lílian M. Costa, Rodrigo M. Feitosa, André V. L. Freitas, Guilherme H. S. Freitas, Conrado A. B. Galdino, José E. Santos Júnior, Felipe S. Leite, Leonardo Lopes, Sandra Ludwig, Maria C. do Nascimento, Daniel Negreiros, Yumi Oki, Henrique Paprocki, Lucas N. Perillo, Fernando A. Perini, Fernando M. Resende, Augusto H. B. Rosa, Luiz F. Salvador, Larissa M. Silva, Luis F. Silveira, Og DeSouza, Emerson M. Vieira and Geraldo Wilson Fernandesadd Show full author list remove Hide full author list
Fire 2023, 6(6), 242; https://doi.org/10.3390/fire6060242 - 18 Jun 2023
Cited by 22 | Viewed by 7842
Abstract
Recent studies have argued that changes in fire regimes in the 21st century are posing a major threat to global biodiversity. In this scenario, incorporating species’ physiological, ecological, and evolutionary traits with their local fire exposure might facilitate accurate identification of species most [...] Read more.
Recent studies have argued that changes in fire regimes in the 21st century are posing a major threat to global biodiversity. In this scenario, incorporating species’ physiological, ecological, and evolutionary traits with their local fire exposure might facilitate accurate identification of species most at risk from fire. Here, we developed a framework for identifying the animal species most vulnerable to extinction from fire-induced stress in the Brazilian savanna. The proposed framework addresses vulnerability from two components: (1) exposure, which refers to the frequency, extent, and magnitude to which a system or species experiences fire, and (2) sensitivity, which reflects how much species are affected by fire. Sensitivity is based on biological, physiological, and behavioral traits that can influence animals’ mortality “during” and “after” fire. We generated a Fire Vulnerability Index (FVI) that can be used to group species into four categories, ranging from extremely vulnerable (highly sensible species in highly exposed areas), to least vulnerable (low-sensitivity species in less exposed areas). We highlight the urgent need to broaden fire vulnerability assessment methods and introduce a new approach considering biological traits that contribute significantly to a species’ sensitivity alongside regional/local fire exposure. Full article
(This article belongs to the Special Issue Recent Progress in Fire Ecology and Management in Tropical and Subtropical Ecosystems)
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