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Authors = Philippe M. Binder

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19 pages, 847 KiB  
Review
Antifragility and Tinkering in Biology (and in Business) Flexibility Provides an Efficient Epigenetic Way to Manage Risk
by Antoine Danchin, Philippe M. Binder and Stanislas Noria
Genes 2011, 2(4), 998-1016; https://doi.org/10.3390/genes2040998 - 29 Nov 2011
Cited by 41 | Viewed by 31734
Abstract
The notion of antifragility, an attribute of systems that makes them thrive under variable conditions, has recently been proposed by Nassim Taleb in a business context. This idea requires the ability of such systems to ‘tinker’, i.e., to creatively respond to changes [...] Read more.
The notion of antifragility, an attribute of systems that makes them thrive under variable conditions, has recently been proposed by Nassim Taleb in a business context. This idea requires the ability of such systems to ‘tinker’, i.e., to creatively respond to changes in their environment. A fairly obvious example of this is natural selection-driven evolution. In this ubiquitous process, an original entity, challenged by an ever-changing environment, creates variants that evolve into novel entities. Analyzing functions that are essential during stationary-state life yield examples of entities that may be antifragile. One such example is proteins with flexible regions that can undergo functional alteration of their side residues or backbone and thus implement the tinkering that leads to antifragility. This in-built property of the cell chassis must be taken into account when considering construction of cell factories driven by engineering principles. Full article
(This article belongs to the Special Issue Evolution and Structure of Proteins and Proteomes 2011)
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