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Authors = Nai-Xun Zhu

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24 pages, 3984 KiB  
Article
Specific siRNA Targeting the Receptor for Advanced Glycation End Products Inhibits Experimental Hepatic Fibrosis in Rats
by Jin-Rong Xia, Nai-Feng Liu and Nai-Xun Zhu
Int. J. Mol. Sci. 2008, 9(4), 638-661; https://doi.org/10.3390/ijms9040638 - 24 Apr 2008
Cited by 42 | Viewed by 11873
Abstract
Receptor for advanced glycation end products (RAGE) was studied in different stages of carbon tetrachloride induced hepatic fibrosis (HF), and effect of its gene silencing in the HF development was evaluated in rats. Silencing RAGE expression by specific siRNA effectively suppressed NF-κB activity, [...] Read more.
Receptor for advanced glycation end products (RAGE) was studied in different stages of carbon tetrachloride induced hepatic fibrosis (HF), and effect of its gene silencing in the HF development was evaluated in rats. Silencing RAGE expression by specific siRNA effectively suppressed NF-κB activity, hepatic stellate cell activation, and accumulation of extracellular matrix proteins in the fibrotic liver, and also greatly improved the histopathology and the ultra-structure of liver cells. These effects may be partially mediated by the inhibition on IκBα degradation. RAGE gene silencing effectively prevented liver from fibrosis, therefore it offers a potential pharmacological tool for anti-HF gene therapy. Full article
(This article belongs to the Section Biochemistry)
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