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Authors = Nadine Müther

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30 pages, 660 KiB  
Review
Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution?
by Nadine Müther, Nadja Noske and Anja Ehrhardt
Viruses 2009, 1(3), 1295-1324; https://doi.org/10.3390/v1031295 - 15 Dec 2009
Cited by 16 | Viewed by 18244
Abstract
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based on these findings major [...] Read more.
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based on these findings major improvements in vector design including the development of viral hybrid vectors for somatic integration have been achieved. This review provides a state-of-the-art overview of available hybrid vectors utilizing viruses for high transduction efficiencies in concert with various integration machineries for random and targeted integration patterns. It discusses advantages but also limitations of each vector system. Full article
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
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