Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Authors = Maria Ignacak

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
4 pages, 231 KiB  
Case Report
Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) with Hard Palate and Bronchial Perforations Treated with Rituximab—A Case Report
by Joanna Kosałka, Stanisława Bazan-Socha, Anna Zugaj, Maria Ignacak, Joanna Żuk, Barbara Sokołowska and Jacek Musiał
Adv. Respir. Med. 2014, 82(5), 454-457; https://doi.org/10.5603/PiAP.2014.0059 - 18 Aug 2014
Cited by 2 | Viewed by 691
Abstract
We present a case of a 57-year-old woman suffering from granulomatosis with polyangiitis (GPA), who in the seventh months of immunosuppressive treatment (cyclophosphamide) progressed with new pulmonary changes and perforations of the hard palate and bronchi. Rituximab was introduced resulting in B-cell depletion [...] Read more.
We present a case of a 57-year-old woman suffering from granulomatosis with polyangiitis (GPA), who in the seventh months of immunosuppressive treatment (cyclophosphamide) progressed with new pulmonary changes and perforations of the hard palate and bronchi. Rituximab was introduced resulting in B-cell depletion and disappearance of anti-PR3 antibody. Palatal holes have substantially diminished and all bronchial perforations disappeared, covered by fibrous tissue. In the fourth month after rituximab administration, large scarring obstruction of the right main bronchus with upper and middle lobes atelectasis emerged. Because of increasing dyspnoea, stenotic bronchus was re-opened by bronchoscopy. Intervention was complicated by bilateral pneumothorax and later, on the seventh day, by fatal pulmonary bleeding. To our knowledge, this is the first report of GPA refractory to cyclophosphamide complicated by palatal and bronchial perforations. Full article
Back to TopTop