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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into numerous lineages with unique spike mutations and caused multiple epidemics domestically and globally. Although COVID-19 vaccines are available, new variants with the capacity for immune evasion continue to emerge. To understand and characterize the evolution of circulating SARS-CoV-2 variants in the U.S., the Centers for Disease Control and Prevention (CDC) initiated the National SARS-CoV-2 Strain Surveillance (NS3) program and has received thousands of SARS-CoV-2 clinical specimens from across the nation as part of a genotype to phenotype characterization process. Focus reduction neutralization with various antisera was used to antigenically characterize 143 SARS-CoV-2 Delta, Mu and Omicron subvariants from selected clinical specimens received between May 2021 and February 2023, representing a total of 59 unique spike protein sequences. BA.4/5 subvariants BU.1, BQ.1.1, CR.1.1, CQ.2 and BA.4/5 + D420N + K444T; BA.2.75 subvariants BM.4.1.1, BA.2.75.2, CV.1; and recombinant Omicron variants XBF, XBB.1, XBB.1.5 showed the greatest escape from neutralizing antibodies when analyzed against post third-dose original monovalent vaccinee sera. Post fourth-dose bivalent vaccinee sera provided better protection against those subvariants, but substantial reductions in neutralization titers were still observed, especially among BA.4/5 subvariants with both an N-terminal domain (NTD) deletion and receptor binding domain (RBD) substitutions K444M + N460K and recombinant Omicron variants. This analysis demonstrated a framework for long-term systematic genotype to antigenic characterization of circulating and emerging SARS-CoV-2 variants in the U.S., which is critical to assessing their potential impact on the effectiveness of current vaccines and antigen recommendations for future updates. Full article

Research conducted within the first year of the pandemic demonstrated that boredom prone individuals were more likely to break rules (e.g., social distancing) aimed at preventing the spread of COVID-19. It is of interest whether this relation persisted deeper into the pandemic, given that initial results may have reflected the extraordinary nature of the early stages of the pandemic on one hand, or more stable dispositions on the other. Therefore, in the Summer of 2021, we administered an online survey to investigate whether boredom proneness predicted COVID-19 rule-breaking over one year into the pandemic (and approximately one year after the earlier studies). We found that boredom prone individuals remained more likely to engage in COVID-19 rule-breaking. Our results suggest that a trait disposition towards boredom exerts a persistent, long-term influence on behaviour, one that is detrimental to personal well-being during the pandemic. Adherence to public health measures might be improved by encouraging individuals to find adaptive ways of coping with boredom. Full article