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Authors = Kojja Venkateswarlu ORCID = 0009-0006-4657-0481

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28 pages, 2930 KiB  
Review
WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective
by Kakarla Ramakrishna, Lakshmi Vineela Nalla, Dumala Naresh, Kojja Venkateswarlu, Matte Kasi Viswanadh, Buchi N. Nalluri, Guntupalli Chakravarthy, Sajusha Duguluri, Payal Singh, Sachchida Nand Rai, Ashish Kumar, Veer Singh and Santosh Kumar Singh
Diseases 2023, 11(3), 89; https://doi.org/10.3390/diseases11030089 - 25 Jun 2023
Cited by 125 | Viewed by 8400
Abstract
Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to adulthood. The canonical pathway of WβC signaling is essential for neurogenesis, cell proliferation, and neurogenesis, whereas the noncanonical pathway (WNT/Ca2+ and [...] Read more.
Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to adulthood. The canonical pathway of WβC signaling is essential for neurogenesis, cell proliferation, and neurogenesis, whereas the noncanonical pathway (WNT/Ca2+ and WNT/PCP) is responsible for cell polarity, calcium maintenance, and cell migration. Abnormal regulation of WβC signaling is involved in the pathogenesis of several neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and spinal muscular atrophy (SMA). Hence, the alteration of WβC signaling is considered a potential therapeutic target for the treatment of neurodegenerative disease. In the present review, we have used the bibliographical information from PubMed, Google Scholar, and Scopus to address the current prospects of WβC signaling role in the abovementioned neurodegenerative diseases. Full article
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