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Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
by
Stefan Grasl, Stefan Janik, Matthaeus C. Grasl, Johannes Pammer, Michael Formanek, Ilan Weinreb, Bayardo Perez-Ordonez, Andrew Hope, Ali Hosni, John R. de Almeida, Jon Irish, Ralph Gilbert, David P. Goldstein and Boban M. Erovic
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Abstract
The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland.
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The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (
p = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69–44.01;
p = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01–0.37;
p = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02–0.59;
p = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.
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