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Authors = Giuseppe E. Grella

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15 pages, 332 KiB  
Article
Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives
by Amedeo Pau, Gabriele Murineddu, Battistina Asproni, Caterina Murruzzu, Giuseppe E. Grella, Gérard A. Pinna, Maria M. Curzu, Irene Marchesi and Luigi Bagella
Molecules 2009, 14(9), 3494-3508; https://doi.org/10.3390/molecules14093494 - 9 Sep 2009
Cited by 16 | Viewed by 9215
Abstract
Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small [...] Read more.
Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively. Full article
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