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Authors = Ginette LaFleche

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21 pages, 435 KiB  
Article
Silent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholics
by Catherine Brawn Fortier, Arkadiy L. Maksimovskiy, Jonathan R. Venne, Ginette LaFleche and Regina E. McGlinchey
Int. J. Environ. Res. Public Health 2009, 6(7), 2007-2027; https://doi.org/10.3390/ijerph6072007 - 20 Jul 2009
Cited by 11 | Viewed by 13477
Abstract
Chronic alcoholism has profound effects on the brain, including volume reductions in regions critical for eyeblink classical conditioning (EBCC). The current study challenged abstinent alcoholics using delay (n = 20) and trace (n = 17) discrimination/reversal EBCC. Comparisons revealed a significant difference between [...] Read more.
Chronic alcoholism has profound effects on the brain, including volume reductions in regions critical for eyeblink classical conditioning (EBCC). The current study challenged abstinent alcoholics using delay (n = 20) and trace (n = 17) discrimination/reversal EBCC. Comparisons revealed a significant difference between delay and trace conditioning performance during reversal (t (35) = 2.08, p < 0.05). The difference between the two tasks for discrimination was not significant (p = 0.44). These data support the notion that alcoholics are increasingly impaired in the complex task of reversing a previously learned discrimination when a silent trace interval is introduced. Alcoholics’ impairment in flexibly altering learned associations may be central to their continued addiction. Full article
(This article belongs to the Special Issue Alcohol and Public Health)
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