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Authors = Frans J. J. de Kanter

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11 pages, 259 KiB  
Communication
Multicomponent Synthesis of 3,6-Dihydro-2H-1,3-thiazine-2-thiones
by Art Kruithof, Marten L. Ploeger, Elwin Janssen, Madeleine Helliwell, Frans J. J. de Kanter, Eelco Ruijter and Romano V. A. Orru
Molecules 2012, 17(2), 1675-1685; https://doi.org/10.3390/molecules17021675 - 8 Feb 2012
Cited by 20 | Viewed by 6510
Abstract
Non-fused 3,6-dihydro-2H-1,3-thiazine-2-thiones constitute a so far rather unexplored class of compounds, with the latest report dating back more than two decades. Thiazine-2-thiones contain an endocyclic dithiocarbamate group, which is often found in pesticides, in substrates for radical chemistry and in synthetic [...] Read more.
Non-fused 3,6-dihydro-2H-1,3-thiazine-2-thiones constitute a so far rather unexplored class of compounds, with the latest report dating back more than two decades. Thiazine-2-thiones contain an endocyclic dithiocarbamate group, which is often found in pesticides, in substrates for radical chemistry and in synthetic intermediates towards thioureas and amidines. We now report the multicomponent reaction (MCR) of in situ-generated 1-azadienes with carbon disulfide. With this reaction, a one-step protocol towards the potentially interesting 3,6-dihydro-2H-1,3-thiazine-2-thiones was established and a small library was synthesized. Full article
(This article belongs to the Special Issue Multicomponent Reaction)
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