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Authors = Festo Damian

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30 pages, 3922 KiB  
Review
Challenges of Dissolution Methods Development for Soft Gelatin Capsules
by Festo Damian, Mohammad Harati, Jeff Schwartzenhauer, Owen Van Cauwenberghe and Shawn D. Wettig
Pharmaceutics 2021, 13(2), 214; https://doi.org/10.3390/pharmaceutics13020214 - 4 Feb 2021
Cited by 38 | Viewed by 17839
Abstract
Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs. This is attributed to the increased number of poorly soluble drugs in the pipeline, and hence the challenges [...] Read more.
Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs. This is attributed to the increased number of poorly soluble drugs in the pipeline, and hence the challenges of finding innovative ways of developing bioavailable and stable dosage forms. Encapsulation of these drugs into SGCs is one of the approaches that is utilized to deliver the active ingredients to the systemic circulation to overcome certain formulation hurdles. Once formulated, encapsulated drugs in the form of SGCs require suitable in vitro dissolution test methods to ensure drug product quality and performance. This review focuses on challenges facing dissolution test method development for SGCs. A brief discussion of the physicochemical and formulation factors that affect the dissolution properties of SGCs will be highlighted. Likewise, the influence of cross-linking of gelatin on the dissolution properties of SGCs will also be discussed. Full article
(This article belongs to the Special Issue Solubilization and Controlled Release of Poorly Water-Soluble Drugs)
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