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Authors = Fakhraddin Naghibalhossaini

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18 pages, 1501 KiB  
Review
The Roles of microRNA miR-185 in Digestive Tract Cancers
by Esmaeel Babaeenezhad, Fakhraddin Naghibalhossaini, Masoumeh Rajabibazl, Zohreh Jangravi, Forouzan Hadipour Moradi, Mohammad Davood Fattahi, Jörg D. Hoheisel, Mostafa Moradi Sarabi and Soroosh Shahryarhesami
Non-Coding RNA 2022, 8(5), 67; https://doi.org/10.3390/ncrna8050067 - 8 Oct 2022
Cited by 11 | Viewed by 2862
Abstract
Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node [...] Read more.
Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches. Full article
(This article belongs to the Section Small Non-Coding RNA)
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