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Authors = Edward SZNELER

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12 pages, 210 KiB  
Article
The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells
by Henryk MARONA, Elżbieta PĘKALA, Agnieszka GUNIA, Zenon CZUBA, Edward SZNELER, Tadeusz SADOWSKI and Wojciech KRÓL
Sci. Pharm. 2009, 77(4), 743-754; https://doi.org/10.3797/scipharm.0906-08 - 17 Oct 2009
Cited by 3 | Viewed by 1600
Abstract
The chemiluminescence of stimulated cells with phorbol myristate acetate and the production of nitric oxide after stimulation with lipopolisaccharide in the presence of the parent compounds FAA (flavone-8-acetic acid = (4-oxo-2- phenyl-4H-chromen-8-yl)acetic acid), XAA (xanthone-4-acetic acid = (9-oxo-9Hxanthen- 4-yl)acetic acid), and [...] Read more.
The chemiluminescence of stimulated cells with phorbol myristate acetate and the production of nitric oxide after stimulation with lipopolisaccharide in the presence of the parent compounds FAA (flavone-8-acetic acid = (4-oxo-2- phenyl-4H-chromen-8-yl)acetic acid), XAA (xanthone-4-acetic acid = (9-oxo-9Hxanthen- 4-yl)acetic acid), and appropriate xanthone derivatives (1–7) was determined. Also the toxicity of the FAA, MFAA ((6-methyl-4-oxo-2-aryl-4H-chromen- 8-yl)acetic acid), XAA and 1–7 against J-774A.1 cultured cells was evaluated. Compound 5 (2-methyl-2-{[(9-oxo-9H-xanthen-2-yl)methyl]sulfanyl}- propanoic acid) was effective in inhibiting chemiluminescence of J-774A.1 cells but most of the other tested compounds stimulated the reaction. FAA and two xanthones with a methoxycarbonyl moeity slightly decreased the generation of nitric oxide at 50 μM. Most of the tested compounds (17) showed weak toxicity at concentration of 100 μM. Full article
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