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Authors = Aprajita Jha ORCID = 0000-0003-2009-8829

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34 pages, 5167 KiB  
Review
Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials
by Atif Khurshid Wani, Nahid Akhtar, Tahir ul Gani Mir, Rattandeep Singh, Prakash Kumar Jha, Shyam Kumar Mallik, Shruti Sinha, Surya Kant Tripathi, Abha Jain, Aprajita Jha, Hari Prasad Devkota and Ajit Prakash
Biomolecules 2023, 13(2), 194; https://doi.org/10.3390/biom13020194 - 18 Jan 2023
Cited by 84 | Viewed by 15108
Abstract
Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle [...] Read more.
Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle progression. Loss of apoptosis control prolongs cancer cell survival and allows the accumulation of mutations that can promote angiogenesis, promote cell proliferation, disrupt differentiation, and increase invasiveness during tumor progression. The apoptotic pathway has been extensively studied as a potential drug target in cancer treatment. However, the off-target activities of drugs and negative implications have been a matter of concern over the years. Phytochemicals (PCs) have been studied for their efficacy in various cancer cell lines individually and synergistically. The development of nanoparticles (NPs) through green synthesis has added a new dimension to the advancement of plant-based nanomaterials for effective cancer treatment. This review provides a detailed insight into the fundamental molecular pathways of programmed cell death and highlights the role of PCs along with the existing drugs and plant-based NPs in treating cancer by targeting its programmed cell death (PCD) network. Full article
(This article belongs to the Special Issue New Advances in Natural Products in Drug Discovery)
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24 pages, 1583 KiB  
Review
Bioaccumulation of Fluoride in Plants and Its Microbially Assisted Remediation: A Review of Biological Processes and Technological Performance
by Rakesh Kumar, Rama Sinha, Pushpa Kumari Sharma, Nishita Ivy, Pawan Kumar, Nishi Kant, Aprajita Jha, Prakash Kumar Jha, Pankaj Kumar Gupta, Prabhakar Sharma, Rakesh Kumar Singh, Rajeev Pratap Singh, Ashok Ghosh and P. V. Vara Prasad
Processes 2021, 9(12), 2154; https://doi.org/10.3390/pr9122154 - 29 Nov 2021
Cited by 39 | Viewed by 10179
Abstract
Fluoride is widely found in soil–water systems due to anthropogenic and geogenic activities that affect millions worldwide. Fluoride ingestion results in chronic and acute toxicity, including skeletal and dental fluorosis, neurological damage, and bone softening in humans. Therefore, this review paper summarizes biological [...] Read more.
Fluoride is widely found in soil–water systems due to anthropogenic and geogenic activities that affect millions worldwide. Fluoride ingestion results in chronic and acute toxicity, including skeletal and dental fluorosis, neurological damage, and bone softening in humans. Therefore, this review paper summarizes biological processes for fluoride remediation, i.e., bioaccumulation in plants and microbially assisted systems. Bioremediation approaches for fluoride removal have recently gained prominence in removing fluoride ions. Plants are vulnerable to fluoride accumulation in soil, and their growth and development can be negatively affected, even with low fluoride content in the soil. The microbial bioremediation processes involve bioaccumulation, biotransformation, and biosorption. Bacterial, fungal, and algal biomass are ecologically efficient bioremediators. Most bioremediation techniques are laboratory-scale based on contaminated solutions; however, treatment of fluoride-contaminated wastewater at an industrial scale is yet to be investigated. Therefore, this review recommends the practical applicability and sustainability of microbial bioremediation of fluoride in different environments. Full article
(This article belongs to the Special Issue Microbial Biotechnology for Environmental Remediation and Restoration)
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