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Authors = Ana María Reverdito

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10 pages, 112 KiB  
Article
Simple and Efficient Microwave Assisted N-Alkylation of Isatin
by María Sol Shmidt, Ana María Reverdito, Lautaro Kremenchuzky, Isabel Amalia Perillo and María Mercedes Blanco
Molecules 2008, 13(4), 831-840; https://doi.org/10.3390/molecules13040831 - 10 Apr 2008
Cited by 90 | Viewed by 15639
Abstract
We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried outunder different conditions, always employing methodologies compatible with MW assistedchemistry. Generation of isatin anion employing diverse bases and solvents or using [...] Read more.
We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried outunder different conditions, always employing methodologies compatible with MW assistedchemistry. Generation of isatin anion employing diverse bases and solvents or using thepreformed isatin sodium salt was tested. The best results were achieved using K2CO3 orCs2CO3 and a few drops of N,N-dimethylformamide or N-methyl-2-pyrrolidinone. Thesereactions present noteworthy advantages over those carried out employing conventionalheating. Full article
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