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Authors = Alicia Corona-Bustamante

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15 pages, 220 KiB  
Article
Antioxidant Activity of Butyl- and Phenylstannoxanes Derivedfrom 2-, 3- and 4-Pyridinecarboxylic Acids
by Alicia Corona-Bustamante, Juan Manuel Viveros-Paredes, Angelina Flores-Parra, Ana Lilia Peraza-Campos, Francisco J. Martínez-Martínez, María Teresa Sumaya-Martínez and Ángel Ramos-Organillo
Molecules 2010, 15(8), 5445-5459; https://doi.org/10.3390/molecules15085445 - 9 Aug 2010
Cited by 60 | Viewed by 15228
Abstract
In vitro antioxidant activity for 12 stannoxanes derived from Ph3SnCl (compounds 1-3), Ph2SnCl2 (compounds 4-6), Bu3SnCl (compounds 7-9), and Bu2SnCl2 (compounds 10-12 [...] Read more.
In vitro antioxidant activity for 12 stannoxanes derived from Ph3SnCl (compounds 1-3), Ph2SnCl2 (compounds 4-6), Bu3SnCl (compounds 7-9), and Bu2SnCl2 (compounds 10-12), was assayed qualitatively by the chromatographic profile with 1,1-diphenyl-2-picrylhydrazil (DPPH) method and by two quantitative methods: the DPPH radical scavenging activity and Ferric-Reducing Antioxidant Power (FRAP) assays. The results were compared with those obtained with the starting materials 2-pyridine- carboxylic acid (I), 3-pyridinecarboxylic acid (II) and 4-pyridinecarboxylic acid (III), as well as with standard compounds, such as vitamin C and vitamin E, respectively. The in vitro antiradical activity with DPPH of diphenyltin derivative 5 showed a very similar behavior to vitamin C at a 20 µg/mL concentration, whereas according to the FRAP method, compound 8 was better. This difference is due to the mechanism of the antioxidant process. The Structure-Activity Relationships (SAR) for both methods is also reported. Full article
(This article belongs to the Special Issue Antioxidants)
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