Search Results (4)

Purpose: Previous studies have reported that blood-based inflammatory markers are associated with prognosis in patients with various solid tumors, including colorectal cancer (CRC). The pan-immune inflammation value (PIV) is a novel prognostic biomarker based on blood count. Here, we aimed to study the association between PIV and survival following transarterial radioembolization (TARE) in patients with liver-dominant metastatic colorectal cancer (CLM). Methods: A total of 49 patients with CLM who underwent TARE at the Ankara University Department of Medical Oncology were retrospectively analyzed. The relationship between clinical and laboratory parameters with post-TARE overall survival (OS) was analyzed by multivariate analyses. Results: The median age was 60 years and 71.4% of patients had received at least two lines of chemotherapy. The objective response rate (ORR) was 59.1% following TARE. Patients with hepatic response after TARE treatment demonstrated significantly longer survival compared to non-responders (p: 0.033). The optimal PIV threshold value was calculated as 629 in ROC analyses. This PIV value had 81% sensitivity and 80% specificity for OS prediction (AUC 0.86; 95% CI: 0.75–0.98, p = 0.008). Patients with elevated PIV > 629 had significantly shorter OS (p = 0.002). In the multivariate analysis, adjusted for ECOG PS, TARE response, presence of extrahepatic disease, number of chemotherapy lines, CEA levels and post-TARE NLR and PIV, only low PIV level was associated with longer OS (>629 vs. ≤629; HR: 4.87; 95% CI: 1.32–17.92; p = 0.017). Conclusions: PIV, a blood-based inflammatory score, may reflect the host’s immune response following TARE and serve as a novel predictor of survival. Full article

The tourism and hospitality sector is known for its excessive consumption of natural resources, waste generation, and negative environmental impacts. The concept of circular economy (CE) has gained increasing attention in recent years as a strategy to promote sustainability and resource efficiency in various industries, including tourism and hospitality. This bibliometric analysis aims to provide a comprehensive overview of current research trends regarding the adoption of CE principles in the tourism and hospitality sector. Unlike conventional methods, a comprehensive bibliometric analysis combined studies from Web of Science and Scopus databases between 2013 and 2024 using the keywords circular economy, tourism, and hospitality. In this research, which includes 314 articles selected in accordance with the PRISMA protocol, it is seen that CE applications are becoming increasingly important. The research results show that there has been a significant increase in the number of publications since 2015; the most productive countries are Italy, Spain, and China, and topics such as waste management and recycling stand out as motor themes. It is thought that the number of studies on practical applications and niche themes should increase and future research suggestions are presented. Full article

The equations of motion and bending of Euler-Bernoulli beam are formulated using the nonlocal elasticity theory for cantilever microtubules (MTs). The method of differential quadrature (DQ) has been used for numerical modeling. The size effect is taken into consideration using the Eringen’s non-local elasticity theory. Frequencies and deflections of MTs are obtained. Numerical results are presented to show the effect of small-scale effect on bending and vibration of MTs. Full article

In this study, free vibration analysis of carbon nanotubes is investigated based on Timoshenko beam theory. Discrete singular convolution (DSC) method is used for free vibration problem of numerical solution of carbon nanotubes. Numerical results are presented and compared with that available in the literature. It is shown that reasonable accurate results are obtained. Full article