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Proceeding Paper

Dietary Consumption of Edible Mushrooms for Disease Prevention: A Literature Overview †

by
Michele Antonelli
1,* and
Davide Donelli
2
1
Department of Public Health, AUSL-IRCCS of Reggio Emilia, 42122 Reggio Emilia, Italy
2
Cardiology Unit, University Hospital of Parma, 43126 Parma, Italy
*
Author to whom correspondence should be addressed.
Presented at the 4th International Electronic Conference on Foods, 15–30 October 2023; Available online: https://foods2023.sciforum.net/.
Biol. Life Sci. Forum 2023, 26(1), 19; https://doi.org/10.3390/Foods2023-15049
Published: 14 November 2023
(This article belongs to the Proceedings of The 4th International Electronic Conference on Foods)

Abstract

:
Edible mushrooms have played a significant role in dietary habits, culinary traditions, folk medicine, myths, and culture since ancient times. This study aims to understand if the regular consumption of edible mushrooms as part of a balanced diet can have some specific beneficial effects on health, especially in preventive medicine. PubMed and Google Scholar were screened for relevant literature reviews, and five articles were included in this work. Overall, mushroom dietary intake was associated with reduced neoplasm incidence, particularly breast cancer, and improved glucose, lipid, and vitamin D levels. However, changes in cholesterol levels were not detected in all studies, and no significant effect was shown for modifications in blood pressure and body weight. In conclusion, the evidence available suggests that a balanced diet including a serving of edible mushrooms at least two-to-three times a week may decrease cancer and metabolic risk in the long run, thus contributing to reducing all-cause mortality risk. The quality of mushrooms and their nutritional characteristics is fundamental to ensure consumer product safety. Further studies should investigate in more depth the effects on health of different mushroom species consumed regularly and the exact minimum amount associated with significant benefits.

1. Introduction

Edible mushrooms have played a significant role in dietary habits, culinary traditions, folk medicine, myths, and culture since ancient times [1]. In particular, mushrooms are neither plants, nor animals, but fungi, thus belonging to a separate biological kingdom, and some of them can be used for nutritional purposes, since they are rich in nutrients and bioactive compounds, including essential amino-acids, glucans, vitamins (thiamine, riboflavin, niacin, tocopherol, vitamin D), minerals (P, K, Na, Ca, Mg, Fe, Mn, Zn, Cu), and fiber [2]. For this reason, edible mushrooms (Figure 1) can be considered de facto as functional foods [3], and some of them (Ganoderma lucidum, Lentinula edodes, Coriolus versicolor, etc.) have recently been studied to create dietary supplements and extracts with medicinal properties (a field of study sometimes referred to as “myco-therapy”) [4]. However, the specific effects on health of regular mushroom consumption and whether this dietary habit can help prevent any diseases have been investigated less extensively, but it could play a useful role in clinical nutrition if some beneficial properties were confirmed.
This study aims to understand if regular consumption of edible mushrooms as a part of a balanced diet can have some specific beneficial effects on health, especially in preventive medicine.

2. Methods

In order to answer our research question, the scientific literature was screened up until February 2023. In particular, PubMed and Google Scholar were searched for relevant review articles describing the effects on health of the dietary consumption of edible mushrooms. The keywords used to search the two databases were “mushroom”, “diet”, “nutrition”, and “review”. The following PICOS criteria were applied for study inclusion and exclusion:
P (Population): healthy subjects or patients with a disease diagnosed in accordance with internationally recognized clinical standards.
I (Intervention): regular consumption of specific edible mushrooms as a part of a balanced diet (studies only assessing the clinical efficacy of mushroom extracts or mushroom-based supplements were excluded from this umbrella review, as the main focus was placed on nutritional habits).
C (Comparison): preferably no (or very low) consumption of edible mushrooms.
O (Outcomes): any health-related outcomes, with a keen focus on epidemiologically relevant disorders (cardiovascular diseases, cancer, mental illnesses, etc.).
S (Study design): Systematic literature reviews coupled or not with a meta-analysis (narrative reviews were only included if the search strategy was sufficiently wide and comprehensive). The methodological quality of all reviews was evaluated on the basis of their compliance with the PRISMA guidelines [5].
The available scientific evidence was briefly summarized and critically discussed in this review of secondary studies.

3. Results

After the scientific literature search, five reviews were included in this work [6,7,8,9,10]. The most relevant characteristics of the reviews included are summarized in Table 1.
All studies involved adult participants, mostly healthy or sub-healthy people, and mushroom intake was either compared with no or very little mushroom consumption [6,7,8,9], or with vitamin supplementation [10]. The follow-up period largely varied from as little as a few days in clinical trials to as much as several years in cohort studies (Table 1). The health outcomes analyzed were those regarding cardiovascular risk factors, metabolic indices, cancer incidence, all-cause mortality risk, and vitamin D levels. Three out of the five reviews were written in compliance with the PRISMA guidelines (Table 1), and one of them was focused on oyster mushroom (Pleurotus ostreatus) properties [8]. Overall, mushroom dietary intake was associated with reduced neoplasm incidence, especially breast cancer, and improved glucose, lipid, and vitamin D levels. However, changes in cholesterol levels were not detected in all studies, and no significant effect was shown for modifications in blood pressure and body weight.

4. Discussion

The mechanism of action of mushroom-derived bioactive compounds has not been fully unraveled yet. Laboratory experiments indicate that many edible and medicinal mushrooms, such as the Ascomycetes and the Basidiomycetes, have antioxidant properties [11,12]. Recent studies have also reported that supplementation of extracts derived from medicinal mushrooms can help boost immune defenses [13], exert a potential antiproliferative effect [14,15], reduce insulin resistance and lipid levels [16,17], show an anticaries action [18], improve mood in patients suffering from major depressive disorder [19], diminish disease-related fatigue [20], and ameliorate cognitive functions in subjects affected by pre-dementia [21]. Some of these therapeutic effects are likely owed to fungal beta-glucans, well known for their immune-modulating and prebiotic effects [22,23]. The relative abundance of polysaccharides, fiber, micronutrients, and, for some mushrooms, the presence of statin-like substances can explain the lipid and glucose lowering effects [24,25]. National surveys also confirm that regular mushroom consumption is usually associated with better nutrient intake and diet quality [26]. However, even though cooking does not seem to significantly reduce the amount of substances such as beta-glucans [27], dietary intake of edible mushrooms is likely to be associated with lower absorption of bioactive compounds if compared to supplementation with concentrated extracts obtained from specific medicinal mushrooms. As such, the effects on health of mushroom consumption are expected to be more limited than those of myco-therapy.
Considering nutritional safety, despite being well tolerated at relatively low doses, edible mushrooms can become toxic when consumed in high quantities [28]. Moreover, since mushrooms tend to concentrate heavy metals and radioactive substances in their body [29,30], strict controls over harvesting areas and food production should be ensured by public health authorities in order to prevent any harmful consequences for consumers. Specific allergies and food intolerances should also be taken into account by clinical nutritionists when prescribing a diet including (or excluding) some mushroom species.

Limitations

This literature overview has some limitations: first of all, this study is based on a bibliographic search and does provide original findings; secondly, the number of primary studies on the topic (either interventional trials or observational experiments) is quite limited; and thirdly, the study quality was not excellent in all instances and future research is warranted to confirm what has been observed and hypothesized so far.

5. Conclusions

In conclusion, the evidence available suggests that a balanced diet including a serving of edible mushrooms at least two-to-three times a week may decrease cancer and metabolic risk in the long run. The quality of mushrooms and their nutritional characteristics is fundamental to ensure consumer product safety. Further studies should investigate in more depth the effects on health of different mushroom species consumed regularly and the exact minimum amount associated with significant benefits. Despite the role of specific foods with beneficial properties, a varied and Mediterranean-style diet remains a key pillar in preventive nutrition.

Author Contributions

Conceptualization, M.A.; Methodology, M.A. and D.D.; Validation, M.A. and D.D.; Investigation, M.A. and D.D.; Resources, M.A. and D.D.; Data Curation, M.A. and D.D.; Writing—Original Draft Preparation, M.A. and D.D.; Writing—Review and Editing, M.A. and D.D.; Visualization, M.A. and D.D.; Supervision, M.A. and D.D.; Project Administration, M.A. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data sharing not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Wasser, S.P. The Importance of Culinary-Medicinal Mushrooms from Ancient Times to the Present. Int. J. Med. Mushrooms 2005, 7, 363–364. [Google Scholar] [CrossRef]
  2. Wang, X.-M.; Zhang, J.; Wu, L.-H.; Zhao, Y.-L.; Li, T.; Li, J.-Q.; Wang, Y.-Z.; Liu, H.-G. A Mini-Review of Chemical Composition and Nutritional Value of Edible Wild-Grown Mushroom from China. Food Chem. 2014, 151, 279–285. [Google Scholar] [CrossRef] [PubMed]
  3. You, S.W.; Hoskin, R.T.; Komarnytsky, S.; Moncada, M. Mushrooms as Functional and Nutritious Food Ingredients for Multiple Applications. ACS Food Sci. Technol. 2022, 2, 1184–1195. [Google Scholar] [CrossRef]
  4. Agrawal, D.C.; Dhanasekaran, M. (Eds.) Medicinal Mushrooms: Recent Progress in Research and Development, 1st ed.; Springer: Singapore, 2019; ISBN 9789811363818. [Google Scholar]
  5. Page, M.J.; McKenzie, J.E.; Bossuyt, P.M.; Boutron, I.; Hoffmann, T.C.; Mulrow, C.D.; Shamseer, L.; Tetzlaff, J.M.; Akl, E.A.; Brennan, S.E.; et al. The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews. Int. J. Surg. 2021, 88, 105906. [Google Scholar] [CrossRef]
  6. Ba, D.M.; Ssentongo, P.; Beelman, R.B.; Muscat, J.; Gao, X.; Richie, J.P. Higher Mushroom Consumption Is Associated with Lower Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies. Adv. Nutr. 2021, 12, 1691–1704. [Google Scholar] [CrossRef]
  7. Ba, D.M.; Gao, X.; Al-Shaar, L.; Muscat, J.; Chinchilli, V.M.; Ssentongo, P.; Zhang, X.; Liu, G.; Beelman, R.B.; Richie, J.P., Jr. Prospective Study of Dietary Mushroom Intake and Risk of Mortality: Results from Continuous National Health and Nutrition Examination Survey (NHANES) 2003–2014 and a Meta-Analysis. Nutr. J. 2021, 20, 80. [Google Scholar] [CrossRef]
  8. Dicks, L.; Ellinger, S. Effect of the Intake of Oyster Mushrooms on Cardiometabolic Parameters-A Systematic Review of Clinical Trials. Nutrients 2020, 12, 1134. [Google Scholar] [CrossRef]
  9. Krittanawong, C.; Isath, A.; Hahn, J.; Wang, Z.; Fogg, S.E.; Bandyopadhyay, D.; Jneid, H.; Virani, S.S.; Tang, W.H.W. Mushroom Consumption and Cardiovascular Health: A Systematic Review. Am. J. Med. 2021, 134, 637–642.e2. [Google Scholar] [CrossRef]
  10. Cardwell, G.; Bornman, J.F.; James, A.P.; Black, L.J. A Review of Mushrooms as a Potential Source of Dietary Vitamin D. Nutrients 2018, 10, 1498. [Google Scholar] [CrossRef]
  11. Mwangi, R.W.; Macharia, J.M.; Wagara, I.N.; Bence, R.L. The Antioxidant Potential of Different Edible and Medicinal Mushrooms. Biomed. Pharmacother. 2022, 147, 112621. [Google Scholar] [CrossRef]
  12. Sarikurkcu, C.; Tepe, B.; Yamac, M. Evaluation of the Antioxidant Activity of Four Edible Mushrooms from the Central Anatolia, Eskisehir—Turkey: Lactarius Deterrimus, Suillus Collitinus, Boletus Edulis, Xerocomus Chrysenteron. Bioresour. Technol. 2008, 99, 6651–6655. [Google Scholar] [CrossRef] [PubMed]
  13. Wang, X.; Lin, Z. Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism. Adv. Exp. Med. Biol. 2019, 1182, 1–37. [Google Scholar] [CrossRef] [PubMed]
  14. Yuen, J.W.M.; Gohel, M.D.I. Anticancer Effects of Ganoderma Lucidum: A Review of Scientific Evidence. Nutr. Cancer 2005, 53, 11–17. [Google Scholar] [CrossRef]
  15. Antonelli, M.; Donelli, D.; Firenzuoli, F. Lentinan for Integrative Cancer Treatment: An Umbrella Review. Proceedings 2020, 83, 1. [Google Scholar] [CrossRef]
  16. Hsu, C.-H.; Liao, Y.-L.; Lin, S.-C.; Hwang, K.-C.; Chou, P. The Mushroom Agaricus Blazei Murill in Combination with Metformin and Gliclazide Improves Insulin Resistance in Type 2 Diabetes: A Randomized, Double-Blinded, and Placebo-Controlled Clinical Trial. J. Altern. Complement. Med. 2007, 13, 97–102. [Google Scholar] [CrossRef]
  17. Hashemi Yusefabad, H.; Hosseini, S.A.; Zakerkish, M.; Cheraghian, B.; Alipour, M. The Effects of Hot Air-Dried White Button Mushroom Powder on Glycemic Indices, Lipid Profile, Inflammatory Biomarkers and Total Antioxidant Capacity in Patients with Type-2 Diabetes Mellitus: A Randomized Controlled Trial. J. Res. Med. Sci. 2022, 27, 49. [Google Scholar] [CrossRef]
  18. Avinash, J.; Vinay, S.; Jha, K.; Das, D.; Goutham, B.S.; Kumar, G. The Unexplored Anticaries Potential of Shiitake Mushroom. Pharmacogn. Rev. 2016, 10, 100–104. [Google Scholar] [CrossRef]
  19. Fijałkowska, A.; Jędrejko, K.; Sułkowska-Ziaja, K.; Ziaja, M.; Kała, K.; Muszyńska, B. Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder. Foods 2022, 11, 1489. [Google Scholar] [CrossRef]
  20. Zhao, H.; Zhang, Q.; Zhao, L.; Huang, X.; Wang, J.; Kang, X. Spore Powder of Ganoderma Lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid. Based. Complement. Alternat. Med. 2012, 2012, 809614. [Google Scholar] [CrossRef]
  21. Mori, K.; Inatomi, S.; Ouchi, K.; Azumi, Y.; Tuchida, T. Improving Effects of the Mushroom Yamabushitake (Hericium Erinaceus) on Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Clinical Trial. Phytother. Res. 2009, 23, 367–372. [Google Scholar] [CrossRef]
  22. Morales, D.; Shetty, S.A.; López-Plaza, B.; Gómez-Candela, C.; Smidt, H.; Marín, F.R.; Soler-Rivas, C. Modulation of Human Intestinal Microbiota in a Clinical Trial by Consumption of a β-D-Glucan-Enriched Extract Obtained from Lentinula Edodes. Eur. J. Nutr. 2021, 60, 3249–3265. [Google Scholar] [CrossRef] [PubMed]
  23. Murphy, E.A.; Davis, J.M.; Carmichael, M.D. Immune Modulating Effects of β-Glucan. Curr. Opin. Clin. Nutr. Metab. Care 2010, 13, 656–661. [Google Scholar] [CrossRef] [PubMed]
  24. Lo, H.-C.; Wasser, S.P. Medicinal Mushrooms for Glycemic Control in Diabetes Mellitus: History, Current Status, Future Perspectives, and Unsolved Problems (review). Int. J. Med. Mushrooms 2011, 13, 401–426. [Google Scholar] [CrossRef] [PubMed]
  25. Kała, K.; Kryczyk-Poprawa, A.; Rzewińska, A.; Muszyńska, B. Fruiting Bodies of Selected Edible Mushrooms as a Potential Source of Lovastatin. Eur. Food Res. Technol. 2020, 246, 713–722. [Google Scholar] [CrossRef]
  26. O’Neil, C.E.; Nicklas, T.A.; Fulgoni, V.L. Mushroom Intake Is Associated with Better Nutrient Intake and Diet Quality: 2001–2010 National Health and Nutrition Examination Survey. J. Nutr. Food Sci. 2013, 3, 1000229. [Google Scholar]
  27. Johansson, L.; Tuomainen, P.; Anttila, H.; Rita, H.; Virkki, L. Effect of Processing on the Extractability of Oat β-Glucan. Food Chem. 2007, 105, 1439–1445. [Google Scholar] [CrossRef]
  28. Nieminen, P.; Mustonen, A.-M. Toxic Potential of Traditionally Consumed Mushroom Species-A Controversial Continuum with Many Unanswered Questions. Toxins 2020, 12, 639. [Google Scholar] [CrossRef]
  29. Thakur, M.P. Advances in Mushroom Production: Key to Food, Nutritional and Employment Security: A Review. Indian Phytopathol. 2020, 73, 377–395. [Google Scholar] [CrossRef]
  30. Kalač, P. A Review of Edible Mushroom Radioactivity. Food Chem. 2001, 75, 29–35. [Google Scholar] [CrossRef]
Figure 1. Examples of edible mushrooms. Legends: Picture distributed under the CC0 Public Domain License and freely accessible at https://eml.wikipedia.org/wiki/File:Edible_Fungi.jpg (access date: 24 February 2023).
Figure 1. Examples of edible mushrooms. Legends: Picture distributed under the CC0 Public Domain License and freely accessible at https://eml.wikipedia.org/wiki/File:Edible_Fungi.jpg (access date: 24 February 2023).
Blsf 26 00019 g001
Table 1. Systematic literature reviews about the effects of mushroom consumption on different health outcomes.
Table 1. Systematic literature reviews about the effects of mushroom consumption on different health outcomes.
PopulationInterventionComparisonFollow-up PeriodHealth-Related OutcomesSDRMCit.
Healthy adultsDietary intake of any edible mushrooms at least two-to-three times a weekLess than one serving of mushrooms per week5–26 years↓ Breast cancer incidence
RR = 0.65 [95% CI: 0.52; 0.81]
↓ Non-breast cancer incidence
RR = 0.80 [95% CI: 0.66; 0.97]
SR + MA (17 studies)PRISMA[6]
Adults interviewed about their nutritional habitsDietary intake of any edible mushroomsNo mushroom consumption6–27 years↓ All-cause mortality risk
RR = 0.94 [95% CI: 0.91; 0.98]
SR + MA (4 studies)PRISMA[7]
Healthy adults or patients with cardiometabolic risk factorsOyster mushroom (Pleurotus ostreatus) 10–200 g/day (lyophilized or fresh)No mushroom consumption7 days–1 year↓ Fasting plasma glucose (6–22%)
↓ Total cholesterol (8–24%)
↓ Triglycerides (20–36%)
↔ HDL cholesterol
↔ Blood pressure
↔ Body weight
SR (7 studies)PRISMA[8]
Adults interviewed about their nutritional habitsDietary intake of any edible mushroomsNo mushroom consumptionMostly 3–24 weeks↓ Total cholesterol
↓ Triglycerides
? Blood pressure
↔ Fasting plasma glucose
SR (7 studies)-[9]
Healthy adultsDietary intake of any edible mushroomsVitamin D supplementation~1 month↑ Vitamin D levels (as much as with vitamin D supplementation)NR-[10]
Legends: MA = meta-analysis; NR = narrative review; SD = study design; RM = review methodology; SR = systematic review. Symbols: ↓ = significantly lower (p < 0.05); ↔ = non-significant difference; ? = inconsistent results.
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Antonelli, M.; Donelli, D. Dietary Consumption of Edible Mushrooms for Disease Prevention: A Literature Overview. Biol. Life Sci. Forum 2023, 26, 19. https://doi.org/10.3390/Foods2023-15049

AMA Style

Antonelli M, Donelli D. Dietary Consumption of Edible Mushrooms for Disease Prevention: A Literature Overview. Biology and Life Sciences Forum. 2023; 26(1):19. https://doi.org/10.3390/Foods2023-15049

Chicago/Turabian Style

Antonelli, Michele, and Davide Donelli. 2023. "Dietary Consumption of Edible Mushrooms for Disease Prevention: A Literature Overview" Biology and Life Sciences Forum 26, no. 1: 19. https://doi.org/10.3390/Foods2023-15049

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