Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders
Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, India
Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea
Department of Medical Genetics, SGPGIMS, Lucknow 226014, India
Department of Neurology, SGPGIMS, Lucknow 226014, India
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Rosanna Di Paola
Biomedicines 2021, 9(2), 99; https://doi.org/10.3390/biomedicines9020099
Received: 9 December 2020 / Revised: 13 January 2021 / Accepted: 19 January 2021 / Published: 20 January 2021
(This article belongs to the Special Issue Natural Medicine in Therapy)
Neurodegenerative disorders, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD), are the most concerning disorders due to the lack of effective therapy and dramatic rise in affected cases. Although these disorders have diverse clinical manifestations, they all share a common cellular stress response. These cellular stress responses including neuroinflammation, oxidative stress, proteotoxicity, and endoplasmic reticulum (ER)-stress, which combats with stress conditions. Environmental stress/toxicity weakened the cellular stress response which results in cell damage. Small molecules, such as flavonoids, could reduce cellular stress and have gained much attention in recent years. Evidence has shown the potential use of flavonoids in several ways, such as antioxidants, anti-inflammatory, and anti-apoptotic, yet their mechanism is still elusive. This review provides an insight into the potential role of flavonoids against cellular stress response that prevent the pathogenesis of neurodegenerative disorders.